Evidence map›Paper›PMID 35762249›Full record

GuidelineNeuro-oncology2022

Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions.

Ayal A Aizer, Nayan Lamba, Manmeet S Ahluwalia, Kenneth Aldape, Adrienne Boire, Priscilla K Brastianos, Paul D Brown, D Ross Camidge, Veronica L Chiang, Michael A Davies and 15 more

Abstract readPractice GuidelineReview
In one paragraph

Guideline in Neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Health-related quality of life and its determinants in patients with malignant brain tumors: a prospective longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Brain metastasis: Opportunities for novel therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Radionecrosis risk and local control after CyberKnifeRadiation oncology (London, England) · 2026
    Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ayal A AizerDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-8941-188X
Nayan LambaDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Manmeet S AhluwaliaDepartment of Medical Oncology, Miami Cancer Institute, Miami, Florida, USA.
Kenneth AldapeLaboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
Adrienne BoireDepartment of Neurology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-9029-1248
Priscilla K BrastianosDepartments of Neuro-Oncology and Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paul D BrownDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
D Ross CamidgeDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Veronica L ChiangDepartments of Neurosurgery and Radiation Oncology, Yale School of Medicine, New Haven, Connecticut, USA.
Michael A DaviesDepartment of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, Texas, USA.
Leland S HuDepartment of Radiology, Neuroradiology Division, Mayo Clinic, Phoenix, Arizona, USA.
Raymond Y HuangDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Timothy KaufmannDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Priya KumthekarDepartment of Neurology at The Feinberg School of Medicine at Northwestern University and The Malnati Brain Tumor Institute at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-5923-0677
Keng LamDepartment of Neurology, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, California, USA.
Eudocia Q LeeDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nancy U LinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Minesh MehtaDepartment of Radiation Oncology, Miami Cancer Institute, Miami, Florida, USA.
Michael ParsonsDepartments of Oncology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8619-9564
David A ReardonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Jason SheehanDepartment of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.
Riccardo SoffiettiDivision of Neuro-Oncology, Department of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID 0000-0002-9204-7038
Hussein TawbiDepartment of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-1942-851X
Michael WellerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1748-174X
Patrick Y WenDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The University of Texas MD Anderson Cancer Center SPORE in MelanomaP50CA221703 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WARGO, JENNIFER A. · 2019 to 2023
$10.3M
Genomic Biomarkers of CancerZIABC011850 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2019 to 2025
$5.1M
Investigating Microenvironmental Interactions in Leptomeningeal MetastasisR01CA245499 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BOIRE, ADRIENNE A. · 2020 to 2024
$2.0M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA221703NCI NIH HHS R01 CA245499
6 · The paper itself

Abstract

Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is known about brain metastases than cancer-related entities of similar incidence. Advances in oncologic care have heightened the importance of intracranial management. Here, in this consensus review supported by the Society for Neuro-Oncology (SNO), we review the landscape of brain metastases with particular attention to management approaches and ongoing efforts with potential to shape future paradigms of care. Each coauthor carried an area of expertise within the field of brain metastases and initially composed, edited, or reviewed their specific subsection of interest. After each subsection was accordingly written, multiple drafts of the manuscript were circulated to the entire list of authors for group discussion and feedback. The hope is that the these consensus guidelines will accelerate progress in the understanding and management of patients with brain metastases, and highlight key areas in need of further exploration that will lead to dedicated trials and other research investigations designed to advance the field.

Indexed as

Brain NeoplasmsConsensusHumansMedical Oncologybrain metastasesconsensusexpertguidelinesrecommendationstreatment

Identifiers

PMID35762249
PMCPMC9527527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.