Evidence map›Paper›PMID 35762188›Full record

ArticleInternal medicine journal2023

Exploring assessment of balance using virtual reality in patients at risk of chemotherapy-induced peripheral neuropathy.

Christina Teng, Elodie Chiarovano, David Tighe, Kim Tam Bui, Venkatesha, Prunella L Blinman, Hamish G MacDougall, Janette L Vardy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Incidence and associated factors of falls in patients with chemotherapy-induced peripheral neuropathy: a scoping review and evidence mapping.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christina TengConcord Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
Elodie ChiarovanoSchool of Psychology, University of Sydney, Sydney, New South Wales, Australia.
David TigheFaculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Kim Tam BuiConcord Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
VenkateshaClinical Research Centre, Sydney Local Health District, Sydney, New South Wales, Australia.
Prunella L BlinmanConcord Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
Hamish G MacDougallSchool of Psychology, University of Sydney, Sydney, New South Wales, Australia.
Janette L VardyConcord Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-5739-5790
The University of Sydney · AUSydney Local Health District · AUUNSW Sydney · AU

Funding

J. L. Vardy is supported by a National Health and Medical Research Council APP1176221The MAST foundation funded virtual reality equipment, and research assistant for data entry.
6 · The paper itself

Abstract

backgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity for people treated for cancer. Impaired balance and falls are functional consequences of CIPN. Virtual reality (VR) technology may be able to assess balance and identify patients at risk of falls.

aimsTo assess the impact of potentially neurotoxic chemotherapy on balance using VR, and explore associations between VR balance assessment, falls and CIPN.

methodsThis prospective, repeated measures longitudinal study was conducted at two Australian cancer centres. Eligible participants were commencing adjuvant chemotherapy containing a taxane for breast cancer, or oxaliplatin for colorectal cancer (CRC), per institutional guidelines. Balance assessments using VR were conducted at baseline, end of chemotherapy and 3 and 6 months after completion of chemotherapy. Participants also completed a comprehensive CIPN assessment comprising clinical and patient-reported outcomes, and recorded falls or near falls.

resultsOut of 34 participants consented, 24 (71%) had breast cancer and 10 (29%) had CRC. Compared to baseline, balance threshold was reduced in 10/28 (36%) evaluable participants assessed at the end of chemotherapy, and persistent in 7/22 (32%) at 6 months. CIPN was identified in 86% at end of chemotherapy and persisted to 6 months after chemotherapy completion in 73%. Falls or near falls were reported by 12/34 (35%) participants, and were associated with impaired VR balance threshold (P = 0.002).

conclusionsWhile VR balance assessment was no better at identifying CIPN than existing measures, it is a potential surrogate method to assess patients at risk of falls from CIPN.

Indexed as

Antineoplastic AgentsBreast NeoplasmsPeripheral Nervous System DiseasesAustraliaFemaleHumansLongitudinal StudiesProspective StudiesAntineoplastic Agentsbalancechemotherapy-induced peripheral neuropathyfallsfalls riskneurotoxicityvirtual reality

Identifiers

PMID35762188
PMCPMC10946840
OpenAlexW4283645842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.