ArticleJournal of clinical periodontology2022
Excessive inflammatory response to infection in experimental peri-implantitis: Resolution by Resolvin D2.
Article in Journal of clinical periodontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- Extracellular Vesicles as Orchestrators of Osteoimmunomodulation in Peri-Implantitis: Implications for Bone Regeneration.Clinical implant dentistry and related research · 2026Review
- Immunomodulation Strategies in Oral Diseases: From Microbiome Manipulation to Pro-resolution Therapies.Advances in experimental medicine and biology · 2026Review
- Graphene oxide-engineered dental implants: orchestrating antibacterial defense and osteo-immunomodulation for enhanced osseointegration.Frontiers in bioengineering and biotechnology · 2026Article
- Peri-Implant Diseases: The Past, the Present, the Future.Journal of periodontal research · 2025Article
- Optimizing delivery of specialized pro-resolving mediators for oral inflammation via smart hydrogels and biomaterials.Therapeutic delivery · 2025Review
- Cargo-less Nanoparticles Prevent Bone Loss in Periodontitis and Peri-implantitis.Journal of dental research · 2025Article
- Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions.Clinical and experimental immunology · 2024Article
- Experimental models for peri-implant diseases: a narrative review.Clinical oral investigations · 2024Review
- Induction of Experimental Peri-Implantitis with Strains Selected from the Human Oral Microbiome.Biomedicines · 2024Article
- [Research Progress in the Molecular Regulatory Mechanisms of Alveolar Bone Restoration].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Predictive factors for the treatment success of peri-implantitis: a protocol for a prospective cohort study.BMJ open · 2024Article
- Immune dysregulation and macrophage polarization in peri-implantitis.Frontiers in bioengineering and biotechnology · 2024Review
- Excessive inflammatory response to infection in experimental peri-implantitis: Resolution by Resolvin D2.Journal of clinical periodontology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimThe aetiology and pathogenesis of peri-implantitis are currently under active research. This study aimed to dissect the pathogenesis of murine experimental peri-implantitis and assess Resolvin D2 (RvD2) as a new treatment modality. MATERIALS AND
methodsFour weeks following titanium implant insertion, mice were infected with Porphyromonas gingivalis using single or multiple oral lavages. RvD2 was administrated following infection, and tissues were analysed using flow cytometry, quantitative RT-PCR, taxonomic profiling, and micro-computed tomography.
resultsRepeated infections with Pg resulted in microbial dysbiosis and a higher influx of innate and adaptive leukocytes to the peri-implant mucosa (PIM) than to gingiva surrounding the teeth. This was accompanied by increased expression levels of IFN-α, IL-1β, and RANKL\OPG ratio. Interestingly, whereas repetitive infections resulted in bone loss around implants and teeth, a single infection induced bone loss only around implants, suggesting a higher susceptibility of the implants to infection. Treatment with RvD2 prevented Pg-driven bone loss and reduced leukocyte infiltration to the PIM.
conclusionsMurine dental implants are associated with dysregulated local immunity and increase susceptibility to pathogen-induced peri-implantitis. However, the disease can be prevented by RvD2 treatment, highlighting the promising therapeutic potential of this treatment modality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.