ArticleJournal of hospital medicine2022
Associations between comorbidity-related functional limitations and pneumonia outcomes.
Article in Journal of hospital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Prevalence of pneumococcal carriage and risk factors for pneumonia and carriage among under-5 children in Malaysia: findings from the MY-Pneumo study.Pneumonia (Nathan Qld.) · 2025Article
- Guideline-Concordant Antibiotic Use in Children With Community-Acquired Pneumonia.Hospital pediatrics · 2025Article
- Application of Short Peptide Enteral Nutrition in Mechanically Ventilated Critically Ill Children with Severe Pneumonia and Its Impact on Patient Recovery.Infection and drug resistance · 2025Article
- Validation of Childhood Pneumonia Prognostic Models for Use in Emergency Care Settings.Journal of the Pediatric Infectious Diseases Society · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundUnderlying comorbidities are common in children with pneumonia.
objectiveTo determine associations between comorbidity-related functional limitations and risk for severe pneumonia outcomes. DESIGN, SETTING, AND
participantsWe prospectively enrolled children <18 years with and without comorbidities presenting to the emergency department with clinical and radiographic pneumonia at two institutions. Comorbidities included chronic conditions requiring daily medications, frequent healthcare visits, or which limited age-appropriate activities. Among children with comorbidities, functional limitations were defined as none or mild, moderate, and severe. MAIN OUTCOMES AND MEASURES: Outcomes included an ordinal severity outcome, categorized as very severe (mechanical ventilation, shock, or death), severe (intensive care without very severe features), moderate (hospitalization without severe features), or mild (discharged home), and length of stay (LOS). Multivariable ordinal logistic regression was used to examine associations between comorbidity-related functional limitations and outcomes, while accounting for relevant covariates.
resultsA cohort of 1116 children, including 452 (40.5%) with comorbidities; 200 (44.2%) had none or mild functional limitations, 93 (20.6%) moderate, and 159 (35.2%) had severe limitations. In multivariable analysis, comorbidity-related functional limitations were associated with the ordinal severity outcome and LOS (p < .001 for both). Children with severe functional limitations had tripling of the odds of a more severe ordinal (adjusted odds ratio [aOR]: 3.01, 95% confidence interval [2.05, 4.43]) and quadrupling of the odds for longer LOS (aOR: 4.72 [3.33, 6.70]) as compared to children without comorbidities.
conclusionComorbidity-related functional limitations are important predictors of disease outcomes in children with pneumonia. Consideration of functional limitations, rather than the presence of comorbidity alone, is critical when assessing risk of severe outcomes.
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