Evidence map›Paper›PMID 35761383›Full record

ArticleTrials2022

Preemptive analgesia for hemorrhoidectomy: study protocol for a prospective, randomized, double-blind trial.

Ekaterina Kazachenko, Tatiana Garmanova, Alexander Derinov, Daniil Markaryan, Hanjoo Lee, Sabrina Magbulova, Petr Tsarkov

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04361695 (Preemptive Analgesia for Hemorrhoidectomy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04361695 naunknown statusnot on this map

Preemptive Analgesia for Hemorrhoidectomy

TypeinterventionalSponsorRussian Society of Colorectal SurgeonsRan2020 to 2022Enrolled144ConditionsHemorrhoidectomyArmsHemorrhoidectomy, Ketoprophenum, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ekaterina KazachenkoSurgical Department, Moscow Research Educational Center of the Lomonosov Moscow State University, Moscow, 101000, Russia.
Tatiana GarmanovaSurgical Department, Moscow Research Educational Center of the Lomonosov Moscow State University, Moscow, 101000, Russia.
Alexander DerinovDepartment: Clinic of Colorectal and Minimally Invasive Surgery, Sechenov First Moscow State Medical University, Moscow, 101000, Russia.
Daniil MarkaryanSurgical Department, Moscow Research Educational Center of the Lomonosov Moscow State University, Moscow, 101000, Russia.
Hanjoo LeeSection of Colorectal Surgery, Department of Surgery, New York Medical College, Westchester Medical Center, Taylor Pavilion, Suite D-361, 100 Woods Road, Valhalla, NY, 10595, USA.
Sabrina MagbulovaDepartment: Clinic of Colorectal and Minimally Invasive Surgery, Sechenov First Moscow State Medical University, Moscow, 101000, Russia. magbulova@kkmx.ru.ORCID http://orcid.org/0000-0002-9045-6145
Petr TsarkovDepartment: Clinic of Colorectal and Minimally Invasive Surgery, Sechenov First Moscow State Medical University, Moscow, 101000, Russia.
Lomonosov Moscow State University · RUSechenov University · RUWestchester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemorrhoidectomy is associated with intense postoperative pain that requires multimodal analgesia. It includes nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and local anesthetics to reach adequate pain control. There are data in literature preemptive analgesia could decrease postoperative pain after hemorrhoidectomy. The aim of this study is to assess the efficacy of preemptive analgesia with ketoprofen 100 mg 2 h before procedure per os with spinal anesthesia to decrease postoperative pain according to visual analog scale and to reduce the opioids and other analgesics consumption.

methodsPatients of our clinic who meet the following inclusion criteria are included: hemorrhoids grade III-IV and the planned Milligan-Morgan hemorrhoidectomy. After signing the consent all participants are randomly divided into 2 groups: the first one gets a tablet with 100 mg ketoprofen, the second one gets a tablet containing starch per os 2 h before surgery (72 participants per arm). Patients of both arms receive spinal anesthesia and undergo open hemorrhoidectomy. Following the procedure the primary and secondary outcomes are evaluated: opioid administration intake, the pain at rest and during defecation, duration, and frequency of other analgesics intake, readmission rate, overall quality of life, time from the procedure to returning to work, and the complications rate. DISCUSSION: Multimodality pain management has been shown to improve pain control and decrease opioid intake in patients after hemorrhoidectomy in several studies. Gabapentin can be considered as an alternative approach to pain control as NSAIDs have limitative adverse effects. Systemic admission of ketorolac with local anesthetics also showed significant efficacy in patients undergoing anorectal surgery. We hope to prove the efficacy of multimodal analgesia including preemptive one for patients undergoing excisional hemorrhoidectomy that will help to hold postoperative pain levels no more than 3-4 points on VAS with minimal consumption of opioid analgesics.

trial registrationClinicalTrial.gov NCT04361695 . Registered on April 24, 2020, version 1.0.

Indexed as

AnalgesiaHemorrhoidectomyHemorrhoidsKetoprofenAnalgesicsAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodHumansPostoperative PainProspective StudiesQuality of LifeRandomized Controlled Trials as TopicAnalgesicsAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalKetoprofenAnalgesicsAnorectal surgeryHemorrhoidectomyPain managementPreemptive analgesia

Identifiers

PMID35761383
PMCPMC9235219
OpenAlexW4283712328

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.