ArticleBrain and behavior2022
Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 9 citations in OpenAlex.
- The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Current pain and headache reports · 2026Review
- The impact of childhood maltreatment and parental styles on telomere length: the modulatory role of A118G.European journal of psychotraumatology · 2025Article
- Anxious-depressive attack and rejection sensitivity-Toward a new approach to treatment-resistant depression.Neuropsychopharmacology reports · 2024Review
- Article
- Is OPRM1 genotype a valuable predictor of VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl?BMC anesthesiology · 2023Article
- Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity.Brain and behavior · 2022Article
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8 authors at 1 institution in 1 country.
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Abstract
backgroundThe μ-opioid receptor (MOR) plays an important role in social bonding behaviors, while it is implicated in the pathophysiology of depression. It is shown that the A118G polymorphism (rs1799971) of the MOR gene (OPRM1) causes amino-acid exchange from Asn to Asp, and that this polymorphism is associated with altered mu-opioid receptor function. Meanwhile, sociotropy/autonomy and interpersonal sensitivity are personality vulnerabilities to depression characterized by distinctive interpersonal styles. The present study tested the hypothesis that the functional A118G OPRM1 polymorphism influences these personality traits.
methodsThe subjects were 402 physically and mentally healthy Japanese volunteers. Sociotropy and autonomy were measured by the Sociotropy-Autonomy Scale, and interpersonal sensitivity was evaluated by the Interpersonal Sensitivity Measure. The A118G polymorphism of the OPRM1 was determined by the PCR method.
resultsIn one factor analysis of covariance, there were differences in scores of sociotropy (uncorrected p < .001, corrected p < .003) and interpersonal sensitivity (uncorrected p = .015, corrected p = .045), but not autonomy, among the A/A, A/G, and G/G genotypes. Post hoc LSD tests showed that sociotropy scores were higher in the A/A group than in the A/G (p = .029) and G/G (p < .001) groups, and higher in the A/G group than in the G/G group (p = .004). Interpersonal sensitivity scores were higher in the A/A group than in the A/G (p = .023) and G/G (p = .009) groups.
conclusionThis study suggests that the A118G OPRM1 polymorphism is associated with sociotropy and interpersonal sensitivity, interpersonal vulnerabilities to depression.
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