Evidence map›Paper›PMID 35761180›Full record

ArticleBMC neurology2022

The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study.

Vilde Nerdal, Elise Gjestad, Ingvild Saltvedt, Ragnhild Munthe-Kaas, Hege Ihle-Hansen, Truls Ryum, Stian Lydersen, Ramune Grambaite

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Risk-predicting and screening tools of post-stroke delirium: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Infection, Inflammation, and Poststroke Cognitive Impairment.Journal of the American Heart Association · 2024
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Vilde Nerdal *Department of Psychology, Norwegian University of Science and Technology, Dragvoll Bygg 12, Edvard Bulls veg 1, 7491, Trondheim, Norway.
Elise Gjestad *Department of Psychology, Norwegian University of Science and Technology, Dragvoll Bygg 12, Edvard Bulls veg 1, 7491, Trondheim, Norway.
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ragnhild Munthe-KaasDepartment of Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Hege Ihle-HansenDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Truls RyumDepartment of Psychology, Norwegian University of Science and Technology, Dragvoll Bygg 12, Edvard Bulls veg 1, 7491, Trondheim, Norway.
Stian LydersenDepartment of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Ramune GrambaiteDepartment of Psychology, Norwegian University of Science and Technology, Dragvoll Bygg 12, Edvard Bulls veg 1, 7491, Trondheim, Norway. ramune.grambaite@ntnu.no.
Norwegian University of Science and Technology · NOSt Olav's University Hospital · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDelirium, a common complication after stroke, is often overlooked, and long-term consequences are poorly understood. This study aims to explore whether delirium in the acute phase of stroke predicts cognitive and psychiatric symptoms three, 18 and 36 months later.

methodAs part of the Norwegian Cognitive Impairment After Stroke Study (Nor-COAST), 139 hospitalized stroke patients (49% women, mean (SD) age: 71.4 (13.4) years; mean (SD) National Institutes of Health Stroke Scale (NIHSS) 3.0 (4.0)) were screened for delirium with the Confusion Assessment Method (CAM). Global cognition was measured with the Montreal Cognitive Assessment (MoCA), while psychiatric symptoms were measured using the Hospital Anxiety and Depression Scale (HADS) and the Neuropsychiatric Inventory-Questionnaire (NPI-Q). Data was analyzed using mixed-model linear regression, adjusting for age, gender, education, NIHSS score at baseline and premorbid dementia.

resultsThirteen patients met the criteria for delirium. Patients with delirium had lower MoCA scores compared to non-delirious patients, with the largest between-group difference found at 18 months (Mean (SE): 20.8 (1.4) versus (25.1 (0.4)). Delirium was associated with higher NPI-Q scores at 3 months (Mean (SE): 2.4 (0.6) versus 0.8 (0.1)), and higher HADS anxiety scores at 18 and 36 months, with the largest difference found at 36 months (Mean (SE): 6.2 (1.3) versus 2.2 (0.3)).

conclusionsSuffering a delirium in the acute phase of stroke predicted more cognitive and psychiatric symptoms at follow-up, compared to non-delirious patients. Preventing and treating delirium may be important for decreasing the burden of post-stroke disability.

Indexed as

Cognitive DysfunctionDeliriumStrokeAgedCognitionFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsProspective StudiesAnxietyCerebrovascular eventCognitive dysfunctionConfusionDepressionMental status and dementia tests

Identifiers

PMID35761180
PMCPMC9235162
OpenAlexW4283579215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.