ArticlePediatric research2023
Maternal risk factors associated with offspring biliary atresia: population-based study.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Biliary Atresia With Situs Inversus Abdominalis Managed by Kasai Portoenterostomy: A Case Report From Muhimbili National Hospital, Tanzania.Clinical case reports · 2026Article
- Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring.Journal of pediatric gastroenterology and nutrition · 2025Article
- Syndromic variants of biliary atresia.World journal of pediatric surgery · 2025Review
- Article
- Biliary atresia with rare associations: a case report and literature review.Annals of medicine and surgery (2012) · 2024Article
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- The Gut-Liver Axis in Pediatric Liver Health and Disease.Microorganisms · 2023Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiliary atresia (BA) is a progressive, idiopathic, fibro-obliterative disease of the intra and extrahepatic biliary tree. If untreated, it results in severe liver injury and death. The etiology and pathogenesis of BA remain unclear. Few studies have investigated the association between maternal illness/drug use and the occurrence of BA in offspring.
methodsWe used the data from the Birth Certificate Application of Taiwan and linked to National Health Insurance Research Database and Taiwan Maternal and Child Health Database for the years 2004 to 2017 (N = 1,647,231) on 2022/03, and identified BA cases according to diagnosis and procedure code. A total of 285 BA cases were identified.
resultsMothers with type 2 diabetes mellitus and non-dependent drug abuse had higher rates having BA children than non-BA children, with an odds ratio of 2.17 (95% confidence interval [CI] = 1.04-4.53) and OR: 3.02 (95% CI = 1.34-6.78), respectively.
conclusionThese results support the notion that BA occurrence is related to maternal reasons. Further studies should be designed to identify additional maternal and pregnancy risk factors and to understand the underlying pathophysiology. IMPACT: 1. The occurrence of offspring biliary atresia may be related to maternal illness/drug use. 2. Maternal drug abuse and type 2 diabetes mellitus pose a high risk for offspring biliary atresia. 3. If maternal etiology is found, biliary atresia might be a preventable disease.
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