ArticleScientific reports2022
Transdiagnostic symptom dynamics during psychotherapy.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Evaluation of a transdiagnostic mental health intervention in German primary care: a parallel-group, two-arm, cluster randomised controlled pilot study.BMC primary care · 2026Trial
- Optimizing just-in-time adaptive interventions for interpersonal distress: mechanisms, prediction, and the challenge of engagement.Scientific reports · 2026Trial
- Symptom Trajectories in Patients With Anxiety Disorders During Transdiagnostic Cognitive Behavioral Therapy.Depression and anxiety · 2026Trial
- Investigating differences in common mental health symptom expression and co-occurrence across ethnicities.BMC global and public health · 2026Article
- Psychological Reserve/External Psychological Control in Psychotherapy: Review and New Models.Behavioral sciences (Basel, Switzerland) · 2026Review
- Specific psychological factors associated with suicidal ideation: a transdiagnostic approach to psychological responses in adolescents.BMC psychology · 2026Article
- Longitudinal panel networks of risk and protective factors for early adolescent suicidality in the ABCD sample.Development and psychopathology · 2025Article
- Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics as a clinical characterisation dimension in the assessment of major depressive disorder.The British journal of psychiatry : the journal of mental science · 2024Article
- Exploring the complexity of commonly held attitudes and beliefs of low back pain-a network analysis.Frontiers in medicine · 2024Article
- Examining bi-directional change in sleep and depression symptoms in individuals receiving routine psychological treatment.Journal of psychiatric research · 2023Article
- Measurement invariance of the PHQ-9 and GAD-7 across males and females seeking treatment for common mental health disorders.BMC psychiatry · 2023Article
- Symptom-specific effects of counselling for depression compared to cognitive-behavioural therapy.BMJ mental health · 2023Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
Psychotherapy is an effective treatment for many common mental health problems, but the mechanisms of action and processes of change are unclear, perhaps driven by the focus on a single diagnosis which does not reflect the heterogeneous symptom experiences of many patients. The objective of this study was to better understand therapeutic change, by illustrating how symptoms evolve and interact during psychotherapy. Data from 113,608 patients from psychological therapy services who completed depression and anxiety symptom measures across three to six therapy sessions were analysed. A panel graphical vector-autoregression model was estimated in a model development sample (N = 68,165) and generalizability was tested in a confirmatory model, fitted to a separate (hold-out) sample of patients (N = 45,443). The model displayed an excellent fit and replicated in the confirmatory holdout sample. First, we found that nearly all symptoms were statistically related to each other (i.e. dense connectivity), indicating that no one symptom or association drives change. Second, the structure of symptom interrelations which emerged did not change across sessions. These findings provide a dynamic view of the process of symptom change during psychotherapy and give rise to several causal hypotheses relating to structure, mechanism, and process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.