Evidence map›Paper›PMID 35760899›Full record

ArticleCancer gene therapy2022

CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9.

Yuwei Zhang, Fengping Liu, Yangkun Feng, Xinyu Xu, Yang Wang, Sha Zhu, Jian Dong, Shanchao Zhao, Bin Xu, Ninghan Feng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer gene therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Potential role ofBiochemistry and biophysics reports · 2026
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  13. Role of Circular RNAs in Prostate Cancer.Current medicinal chemistry · 2024
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yuwei Zhang *Department of Urology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China.ORCID http://orcid.org/0000-0003-1337-1081
Fengping Liu *Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Yangkun Feng *Medical College of Nantong University, Nantong, China.
Xinyu XuDepartment of Urology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China.
Yang WangDepartment of Urology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China.
Sha ZhuDepartment of Oncology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China.
Jian DongDepartment of Urology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China.
Shanchao ZhaoDepartment of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. zhaoshanchao@263.net.ORCID http://orcid.org/0000-0002-1162-8077
Bin XuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China. njxbseu@seu.edu.cn.ORCID http://orcid.org/0000-0003-4993-0500
Ninghan FengDepartment of Urology, Affiliated Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, China. n.feng@njmu.edu.cn.ORCID http://orcid.org/0000-0002-0892-6102
Wuxi No.2 People's Hospital · CNNantong University · CNJiangnan University · CNThird Affiliated Hospital of Southern Medical University · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have been demonstrated to play vital roles in cancer development and progression. However, studies on the association between circRNAs and prostate cancer (PCa) are still lacking. CircRNA sequencing of two pairs of PCa tissues and adjacent normal tissues was conducted in the present study, and qRT-PCR was performed to verify the results. Functional experiments were performed to investigate cellular functions after specific changes. Mass spectrometry analysis after RNA pull-down experiments and Co-IP assays were further conducted. Downstream target proteins were predicted via online databases and detected in vitro by Western blot analysis and in vivo by immunohistochemistry. Hsa_circ_0006156 (subsequently named circ_0006156) expresses at low levels in both PCa tissues and cells, and it significantly inhibits the migration and invasion of PCa cells. Circ_0006156 binds to and blocks the ubiquitination of S100A9. Moreover, functional assays revealed that circ_0006156 represses the malignant progression of PCa by binding to S100A9. Finally, in vivo experiments showed that circ_0006156 suppresses PCa migration and invasion by increasing S100A9, revealing circ_0006156 as a potential novel effective target for PCa treatment.

Indexed as

MicroRNAsProstatic NeoplasmsCell Line, TumorCell ProliferationHumansMaleRNA, CircularUbiquitinationMicroRNAsRNA, Circular

Identifiers

PMID35760899
PMCPMC9663304
OpenAlexW4283582902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.