Evidence map›Paper›PMID 35760787›Full record

ArticleNature communications2022

Recovery of neural dynamics criticality in personalized whole-brain models of stroke.

Rodrigo P Rocha, Loren Koçillari, Samir Suweis, Michele De Filippo De Grazia, Michel Thiebaut de Schotten, Marco Zorzi, Maurizio Corbetta

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
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  6. Article
  7. TVB C++: A Fast and Flexible Back-End for The Virtual Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025
    Article
  9. Review
  10. Article
  11. Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Measurement effects on critical scaling in neural systems.Frontiers in computational neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rodrigo P RochaDepartamento de Física, Centro de Ciências Físicas e Matemáticas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil. rodrigo.rocha@ufsc.br.ORCID http://orcid.org/0000-0001-5651-3567
Loren KoçillariPadova Neuroscience Center, Università di Padova, Padova, Italy.
Samir SuweisPadova Neuroscience Center, Università di Padova, Padova, Italy.
Michele De Filippo De GraziaIRCCS San Camillo Hospital, Venice, Italy.ORCID http://orcid.org/0000-0003-3682-8582
Michel Thiebaut de SchottenBrain Connectivity and Behaviour Laboratory, BCBlab, Sorbonne Universities, Paris, France.ORCID http://orcid.org/0000-0002-0329-1814
Marco ZorziIRCCS San Camillo Hospital, Venice, Italy.ORCID http://orcid.org/0000-0002-4651-6390
Maurizio CorbettaPadova Neuroscience Center, Università di Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-8295-3304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal and external inputs. Criticality thus provides optimal function and behavioral capabilities. We test this hypothesis by examining the influence of brain injury (strokes) on the criticality of neural dynamics estimated at the level of single participants using directly measured individual structural connectomes and whole-brain models. Lesions engender a sub-critical state that recovers over time in parallel with behavior. The improvement of criticality is associated with the re-modeling of specific white-matter connections. We show that personalized whole-brain dynamical models poised at criticality track neural dynamics, alteration post-stroke, and behavior at the level of single participants.

Indexed as

ConnectomeStrokeBrainHumansModels, NeurologicalNeurons

Identifiers

PMID35760787
PMCPMC9237050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.