Evidence map›Paper›PMID 35759660›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer.

Joshua A Korsen, Julia A Gutierrez, Kathryn M Tully, Lukas M Carter, Zachary V Samuels, Samantha Khitrov, John T Poirier, Charles M Rudin, Yu Chen, Michael J Morris and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 53 citations in OpenAlex.

  1. Imaging with [The Lancet. Oncology · 2024
    Trial
  2. Review
  3. Article
  4. Delta-like Ligand 3-DirectedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Review
  6. Review
  7. Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Combination therapy strategies in engineeredCell communication and signaling : CCS · 2026
    Review
  9. Review
  10. The Olive PhenolicCancers · 2025
    Article
  11. Review
  12. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  13. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  14. Review
  15. Article
  16. Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Joshua A KorsenDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Julia A GutierrezDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-9024-7482
Kathryn M TullyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Lukas M CarterDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0003-4848-4190
Zachary V SamuelsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-6639-5402
Samantha KhitrovDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-3275-0282
John T PoirierPerlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Charles M RudinDepartment of Pharmacology, Weill Cornell Medicine, New York, NY 10021.ORCID 0000-0001-5204-3465
Yu ChenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Michael J MorrisDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-9454-0096
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-6930-7383
Nagavarakishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-1750-7436
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-7065-4534
Memorial Sloan Kettering Cancer Center · USNYU Langone Health · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
SPORE In Prostate CancerP50CA092629 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI David B. Solit · 2001 to 2026
$63.0M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Novel therapeutic development for small cell lung cancerR35CA263816 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Charles M. Rudin · 2021 to 2026
$6.3M
Predoctoral Training in Pharmacological SciencesT32GM073546 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2006 to 2020
$3.1M
Preclinical development of a DLL3-targeted theranostic for small cell lung cancerU01CA213359 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POIRIER, JOHN THOMAS · 2017 to 2021
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA092629NCI NIH HHS R35 CA232130NCI NIH HHS R35 CA263816NCI NIH HHS U01 CA213359NIGMS NIH HHS T32 GM073546
6 · The paper itself

Abstract

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer with limited meaningful treatment options. NEPC lesions uniquely express delta-like ligand 3 (DLL3) on their cell surface. Taking advantage of DLL3 overexpression, we developed and evaluated lutetium-177 (

Indexed as

Antibodies, Monoclonal, HumanizedCarcinoma, NeuroendocrineIntracellular Signaling Peptides and ProteinsMembrane ProteinsProstatic NeoplasmsRadioimmunotherapyAnimalsChelating AgentsHumansLigandsLutetiumMaleMicePentetic AcidRadioisotopesXenograft Model Antitumor AssaysAntibodies, Monoclonal, HumanizedChelating AgentsDLL3 protein, humanIntracellular Signaling Peptides and ProteinsLigandsLutetiumLutetium-177Membrane ProteinsPentetic AcidRadioisotopesDLL3lutetium-177neuroendocrine prostate cancerradioimmunotherapy

Identifiers

PMID35759660
PMCPMC9271187
OpenAlexW4283577156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.