Evidence map›Paper›PMID 35759125›Full record

ReviewClinical rheumatology2022

Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review.

Xuxia He, Yubing Wen, Rongrong Hu, Haiting Wu, Wei Ye, Cai Yue, Yan Qin, Peng Xia, Limeng Chen

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xuxia HeDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0002-9218-6409
Yubing WenDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0003-0438-8447
Rongrong HuDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0002-2238-3431
Haiting WuDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0003-2950-7801
Wei YeDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0002-8211-1956
Cai YueDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0001-5754-0225
Yan QinDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.ORCID http://orcid.org/0000-0002-2958-8122
Peng XiaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. 7-xp@163.com.ORCID http://orcid.org/0000-0003-0098-8429
Limeng ChenDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. chenlimeng@pumch.cn.ORCID http://orcid.org/0000-0002-8425-5742
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Beijing Natural Science Foundation L202035Capital's Funds for Health Improvement and Research CFH 2020-2-4018the CAMS Innovation Fund for Medical Sciences CIFMS 2020-I2M-C&T-A-001the CAMS Innovation Fund for Medical Sciences CIFMS 2021-I2M-1-003the CAMS Innovation Fund for Medical Sciences CIFMS 2021-I2M-C&T-B-011
6 · The paper itself

Abstract

The typical nephrological presentation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rapidly progressive glomerulonephritis. AAV-associated interstitial nephritis without apparent glomerular lesions was rare. We reported three local cases of AAV-associated interstitial nephritis without glomerulonephritis confirmed by renal biopsy. Then, a literature search was conducted in PubMed using free text words and MeSH terms related to "AAV and interstitial nephritis". Fifteen cases were included, and their demographics, clinical manifestations, laboratory data, renal pathological features, and treatment response were summarized. AAV-associated interstitial nephritis usually affects elderly patients. The common symptoms include fever, arthralgias, and edema. These patients were mostly MPO-ANCA positive. Pathological lesions in the kidney showed diffuse infiltration of inflammatory cells, edema, tubulitis, and fibrosis in the interstitial area. Various immunosuppressive treatments, including glucocorticoids, immunosuppressants, and rituximab, were used, and most of the patients achieved clinical remission. AAV-associated interstitial nephritis is rare but shows a characteristic clinical phenotype, serological results, and pathogenic lesions. Immunosuppressive therapy showed good efficacy in these patients.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisGlomerulonephritisNephritis, InterstitialAntibodies, Antineutrophil CytoplasmicHumansImmunosuppressive AgentsRituximabAntibodies, Antineutrophil CytoplasmicImmunosuppressive AgentsRituximabANCA-associated vasculitisCase reportsInterstitial nephritisLiterature review

Identifiers

PMID35759125
PMCPMC9568481
OpenAlexW4283645777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.