Evidence map›Paper›PMID 35759082›Full record

ReviewMolecular biology reports2022

Immunotherapy: an alternative promising therapeutic approach against cancers.

Sneh Lata Gupta, Srijani Basu, Vijay Soni, Rishi K Jaiswal

Abstract readReview
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sneh Lata Gupta *National Institute of Immunology, New Delhi, 110067, India.
Srijani Basu *National Institute of Immunology, New Delhi, 110067, India.
Vijay Soni *Division of Infectious Disease, Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
Rishi K JaiswalDepartment of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA. rishijai24@gmail.com.ORCID http://orcid.org/0000-0003-2180-318X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. Many immunotherapeutic methodologies, including adaptive cancer therapy, cancer peptide vaccines, monoclonal antibodies, and immune checkpoint treatment, have transformed the traditional cancer treatment landscape. However, many questions remain unaddressed. The development of personalized combination therapy and neoantigen-based cancer vaccines would be the avant-garde approach to cancer treatment. Desirable chemotherapy should be durable, safe, and target-specific. Managing both tumor (intrinsic factors) and its microenvironment (extrinsic factors) are critical for successful immunotherapy. This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus.

Indexed as

Cancer VaccinesNeoplasmsAntibodies, MonoclonalCytokinesHumansImmunologic FactorsImmunotherapyImmunotherapy, AdoptiveTumor MicroenvironmentAntibodies, MonoclonalCancer VaccinesCytokinesImmunologic FactorsChimeric Antigen Receptor (CAR)Interferon gamma (IFN-ɣ)Peripheral Blood Mononuclear Cells (PBMCs)Programmed death ligand (PD-L1)Tumor Necrosis Factor (TNF)

Identifiers

PMID35759082
PMCPMC9244230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.