Evidence map›Paper›PMID 35758750›Full record

ArticleJournal of bacteriology2022

Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions.

Casandra Ai Zhu Tan, Ling Ning Lam, Goran Biukovic, Eliza Ye-Chen Soh, Xiao Wei Toh, José A Lemos, Kimberly A Kline

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Journal of bacteriology · 2026
    Article
  2. Role of Iron Availability in ModulatingJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Respiratory Microbiome of Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  7. Genome-wide analysis ofJournal of bacteriology · 2025
    Article
  8. Article
  9. mBio · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Efflux, Signaling and Warfare in a Polymicrobial World.Antibiotics (Basel, Switzerland) · 2023
    Review
  18. Role ofJournal of oral microbiology · 2023
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Casandra Ai Zhu TanSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.ORCID 0000-0002-4637-488X
Ling Ning LamDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0003-0568-8628
Goran BiukovicSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.
Eliza Ye-Chen SohSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.
Xiao Wei TohSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.
José A LemosDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0003-0791-5863
Kimberly A KlineSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.ORCID 0000-0002-5472-3074
Nanyang Technological University · SGUniversity of Florida · US

Funding

HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21 AI 37446Ministry of Education - Singapore (MOE) MOE2014-T2-1-129National Research Foundation Singapore (NRF) RCE-SCELSE
6 · The paper itself

Abstract

Enterococcus faecalis is often coisolated with Pseudomonas aeruginosa in polymicrobial biofilm-associated infections of wounds and the urinary tract. As a defense strategy, the host innately restricts iron availability at infection sites. Despite their coprevalence, the polymicrobial interactions of these two species in biofilms and under iron-restricted conditions remain unexplored. Here, we show that E. faecalis inhibits P. aeruginosa growth within biofilms when iron is restricted. E. faecalis lactate dehydrogenase (

Indexed as

Enterococcus faecalisPseudomonas aeruginosaBiofilmsIronLactic AcidIronLactic AcidEnterococcus faecalisiron restrictionlactate dehydrogenase (LDH)l-lactatemixed speciespolymicrobial interactionsPseudomonas aeruginosa

Identifiers

PMID35758750
PMCPMC9295543
OpenAlexW4283584616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.