ArticleeLife2022
Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
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Who cites it
49 citing papers in PubMed, 63 citations in OpenAlex.
- Reprogramming bone homeostasis: The recoupling-oriented framework of bidirectional regulation strategies for osteoporosis.iScience · 2026Review
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- Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis.Redox biology · 2026Article
- Surface protein profiling reveals depot-specific features of subcutaneous and visceral adipose progenitor cells.Biochemistry and biophysics reports · 2026Article
- Promoting Bone Health in Layer Chickens from the Perspective of Mitochondrial Energy Metabolism in Osteoclasts.Animals : an open access journal from MDPI · 2026Review
- Angiogenin mediates cell-cell fusion as a mitochondrial RNA processing enzyme.Bone research · 2026Article
- FTMT-mediated suppression of mitophagy links iron accumulation to osteoporosis.Redox biology · 2026Article
- Transcriptome Analysis of Differentially Expressed Genes and Molecular Pathways Involved During Osteoclast Differentiation.Molecular biotechnology · 2026Article
- Article
- Osteocytes regulate osteoprotegerin expression via the p38-MAPK-CREB pathway in rheumatoid arthritis.JBMR plus · 2026Article
- The osteoclast intracellular environment fosters bacterial growth duringbioRxiv : the preprint server for biology · 2026Article
- LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2.Cell biology and toxicology · 2026Article
- The Interplay Between Bone Biology and Iron Metabolism: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- The iron-ferroptosis axis in bone homeostasis: a potential complementary pathway for osteoporosis in endometriosis.European journal of medical research · 2026Review
- Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Glutamine synthetase shields triple-negative breast cancer cells from ferroptosis in metastasis triggered by glutamine deprivation.Breast cancer research : BCR · 2025Article
- Bone phenotype in male and female mice after knockdown of transferrin receptor 1 in osterix-expressing cells.JBMR plus · 2025Article
- Transferrin receptors.Experimental & molecular medicine · 2025Review
- Mitochondria derived from Stem cells modulated the biological behavior of monocyte-macrophages and inhibited inflammatory bone resorption.BMC musculoskeletal disorders · 2025Article
- The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo.Nature communications · 2025Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 3 countries.
Bhaba K Das *Southern California Institute for Research and Education, Long Beach, United States.ORCID 0000-0003-0256-5489
Lei Wang *Department of Orthopedics, The Third People's Hospital of Hefei, Third Clinical College, Anhui Medical University, Hefei, China.
Toshifumi Fujiwara *Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, United States.
Jian ZhouDepartment of Orthopedics, First Affiliated Hospital, Anhui Medical University, Hefei, China.
Nukhet Aykin-BurnsDivision of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, United States.ORCID 0000-0001-8574-4102
Kimberly J KragerDivision of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, United States.
Renny LanDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, United States.
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, United States.
Ricky EdmondsonDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, United States.
Michael L JenningsDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, United States.
Xiaofang WangDepartment of Biomedical Sciences, Texas A&M University, Dallas, United States.
Jian Q FengDepartment of Biomedical Sciences, Texas A&M University, Dallas, United States.
Tomasa BarrientosDepartment of Orthopedics, Duke University, Durham, United States.
Jyoti GogoiSouthern California Institute for Research and Education, Long Beach, United States.
Aarthi KannanSouthern California Institute for Research and Education, Long Beach, United States.
Ling GaoSouthern California Institute for Research and Education, Long Beach, United States.
Weirong XingMusculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, United States.
Subburaman MohanMusculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, United States.ORCID 0000-0003-0063-986X
Haibo ZhaoSouthern California Institute for Research and Education, Long Beach, United States.ORCID 0000-0003-0836-7555
University of Arkansas for Medical Sciences · USSouthern California Institute for Research and Education · USAnhui Medical University · CNTexas A&M University · USVA Loma Linda Healthcare System · USDuke University Hospital · USKyushu University Hospital · JP
Funding
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Samrat Roy Choudhury · 2017 to 2026
$27.6MThe Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PARKER, PEARMAN · 2015 to 2024
$21.1MSupplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4MTransgenic Approaches to Evaluate IGF-I Role in Peak BMDR01AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH &EDUC · PI MOHAN, SUBBURAMAN · 2003 to 2025
$4.7MMechanisms of Cytoskeletal and Lysosomal Protein Regulation in OsteoclastsR01AR062012 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI ZHAO, HAIBO · 2011 to 2015
$1.6MRole and Mechanism of Claudin-11 Action and Signaling in BoneR01AR070806 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2017 to 2023
$1.6MMolecular Mechanisms of LRRK1 Regulation of Bone HomeostasisR01AR078843 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI Weirong Xing · 2022 to 2026
$1.3MMolecular mechanisms of lysosome secretion in osteoclasts and bone HomeostasisR01AR073298 · NIAMS · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI ZHAO, HAIBO · 2019 to 2022
$1.2MStructural and functional analyses of Rab7 binding to Plekhm1R21AR068509 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI VARUGHESE, KOTTAYIL I, ZHAO, HAIBO · 2016 to 2017
$361kPreclinical investigation of PI3K inhibition and immune checkpoint blockade combination therapy for treatment of Merkel cell carcinoma using humanized mouse modelsI01BX004841 · VA · VETERANS HEALTH ADMINISTRATION · PI GAO, LING · 2020 to 2023
–BLRD VA I01 BX004841BLRD VA IK6 BX005381NIAMS NIH HHS R01 AR048139NIAMS NIH HHS R01 AR062012NIAMS NIH HHS R01 AR070806NIAMS NIH HHS R01 AR073298NIAMS NIH HHS R01 AR078843NIAMS NIH HHS R21 AR068509NIGMS NIH HHS P20 GM109005NIGMS NIH HHS P20 GM121293NIGMS NIH HHS R24 GM137786
Abstract
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular iron uptake through endocytosis of iron-loaded transferrin, and its expression increases during osteoclast differentiation. Nonetheless, the precise functions of Tfr1 and Tfr1-mediated iron uptake in osteoclast biology and skeletal homeostasis remain incompletely understood. To investigate the role of Tfr1 in osteoclast lineage cells in vivo and in vitro, we crossed
Indexed as
Bone ResorptionIronOsteoclastsReceptors, TransferrinAnimalsCytoskeletonFemaleMiceMice, KnockoutMitochondriaIronReceptors, TransferrinTfrc protein, mousebone remodelingbone resorptioncell biologymitochondriamouseosteoclasttransferrintransferrin receptor 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.