Evidence map›Paper›PMID 35758541›Full record

ArticleStem cells translational medicine2022

Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip.

Stefano Negri, Yiyun Wang, Zhao Li, Qizhi Qin, Seungyong Lee, Masnsen Cherief, Jiajia Xu, Ginny Ching-Yun Hsu, Robert Joel Tower, Bradley Presson and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Tppp3Bone research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Stefano NegriDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-2218-6654
Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Zhao LiDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Qizhi QinDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Seungyong LeeDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Masnsen CheriefDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Jiajia XuDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Ginny Ching-Yun HsuDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5923-3413
Robert Joel TowerCenter for Organogenesis Research and Trauma, University of Texas Southwestern, Dallas, TX, USA.
Bradley PressonOrthopaedic and Trauma Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology of the University of Verona, Verona, Italy.
Adam LevinDepartment of Orthopaedics, Johns Hopkins University, Baltimore, MD, USA.
Edward McCarthyDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Benjamin LeviCenter for Organogenesis Research and Trauma, University of Texas Southwestern, Dallas, TX, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USOrganogenesis (United States) · USUniversity of Verona · IT

Funding

Targeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5M
Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
Developing New Diagnostic and Timed, TAK1 Specific Treatment Strategies for Trauma Induced Heterotopic OssificationR01GM123069 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2020
$1.2M
TIAM1 dictates lineage commitment in skeletal and soft tissue pericytesK08DE031347 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI Ginny Ching-Yun Hsu · 2022 to 2026
$830k
Neutrophil Biomarker and neutrophil targeted therapy to predict and prevent heterotopic ossificationR61AR078072 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2020 to 2021
$786k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
NIAMS NIH HHS R01 AR070773NIAMS NIH HHS R01 AR071379NIAMS NIH HHS R61 AR078072NIDCR NIH HHS K08 DE031347NIDCR NIH HHS R21 DE027922NIGMS NIH HHS R01 GM123069NIH HHS R01GM123069
6 · The paper itself

Abstract

Heterotopic ossification (HO) is a pathologic process characterized by the formation of bone tissue in extraskeletal locations. The hip is a common location of HO, especially as a complication of arthroplasty. Here, we devise a first-of-its-kind mouse model of post-surgical hip HO and validate expected cell sources of HO using several HO progenitor cell reporter lines. To induce HO, an anterolateral surgical approach to the hip was used, followed by disclocation and acetabular reaming. Animals were analyzed with high-resolution roentgenograms and micro-computed tomography, conventional histology, immunohistochemistry, and assessments of fluorescent reporter activity. All the treated animals' developed periarticular HO with an anatomical distribution similar to human patients after arthroplasty. Heterotopic bone was found in periosteal, inter/intramuscular, and intracapsular locations. Further, the use of either PDGFRα or scleraxis (Scx) reporter mice demonstrated that both cell types gave rise to periarticular HO in this model. In summary, acetabular reaming reproducibly induces periarticular HO in the mouse reproducing human disease, and with defined mesenchymal cellular contributors similar to other experimental HO models. This protocol may be used in the future for further detailing of the cellular and molecular mediators of post-surgical HO, as well as the screening of new therapies.

Indexed as

Arthroplasty, Replacement, HipMesenchymal Stem CellsOssification, HeterotopicAnimalsArthroplastyHumansMiceStem CellsX-Ray Microtomographyheterotopic bonehip arthroplastymyositis ossificansPDGFRscleraxis

Identifiers

PMID35758541
PMCPMC9397657
OpenAlexW4283579080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.