ArticleGut microbes
Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 57 citations in OpenAlex.
- Bridging the gap:Gut microbes · 2026Review
- Protocatechuic acid attenuated inflammation caused byVirulence · 2026Article
- Article
- Host-Microbiota Interactions in the Regulation of Intestinal Health in Weaned Piglets: Molecular Mechanisms and Nutritional Intervention Strategies.Animals : an open access journal from MDPI · 2026Review
- Polysaccharides and Glycosides fromPharmaceuticals (Basel, Switzerland) · 2026Article
- Metagenomic sequencing reveals the dynamic changes of pig gut fungal composition following the ages and identifies fungal species associated with diarrhea in piglets.Animal microbiome · 2026Article
- Lemongrass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- From predisposition to recovery: field evidence of interactions between the gut microbiota and Brachyspira hyodysenteriae infection.Veterinary research · 2026Article
- Widely targeted metabolomics and machine learning identify succinate as a key metabolite in sepsis-associated encephalopathy.iScience · 2026Article
- Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets.Current pharmaceutical design · 2026Article
- Effect of Replacing Corn with Rice on Growth Performance, Meat Quality, Gut Microbiota and Metabolites in Growing-Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions.Journal of animal science and biotechnology · 2025Article
- Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization.Gut microbes · 2025Article
- Taking intestinal microbes and the immune system as opportunities to maintain the intestinal health of piglets: review.Animal bioscience · 2025Article
- Exploring the Gut Microbiota-Retina Axis: Implications for Health and Disease.Microorganisms · 2025Review
- Gut microbes-muscle axis in muscle function and meat quality.Science China. Life sciences · 2025Review
- Genome-wide association study and subsequent functional analysis reveal regulatory mechanism underlying piglet diarrhea.Animal bioscience · 2025Article
- Assessing the potential for non-digestible carbohydrates toward mitigating adverse effects of antibiotics on microbiota composition and activity in an in vitro colon model of the weaning infant.FEMS microbiology ecology · 2025Article
- Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis.NPJ biofilms and microbiomes · 2025Article
- Expression of recombination antimicrobial protein PIL22-PBD-2 in Pichia pastoris and verification of its biological function in vitro.Veterinary research · 2025Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim to elucidate and enrich the mechanistic basis of diarrhea. We found significant alterations in fecal microbiome, their metabolites, and microRNAs levels in piglets with diarrhea. Specifically, loss of ssc-miRNA-425-5p and ssc-miRNA-423-3p, which inhibit the gene expression of fumarate reductase (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.