Evidence map›Paper›PMID 35757822›Full record

ArticleIJID regions2021

Antimicrobial susceptibility testing profiles of ESBL-producing

Onduru G Onduru, Said Aboud, Tonney S Nyirenda, Susan F Rumisha, Rajhab S Mkakosya

Open access · goldAbstract read
In one paragraph

Article in IJID regions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Onduru G OnduruDepartment of Pathology, College of Medicine, Kamuzu University of Health Sciences, Private Bag 360, Blantyre, Malawi.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Tonney S NyirendaDepartment of Pathology, College of Medicine, Kamuzu University of Health Sciences, Private Bag 360, Blantyre, Malawi.
Susan F RumishaDirectorate of Information Technology and Communication, National Institute for Medical Research, P.O. Box 9653, Dar es Salaam, Tanzania.
Rajhab S MkakosyaDepartment of Pathology, College of Medicine, Kamuzu University of Health Sciences, Private Bag 360, Blantyre, Malawi.
Kamuzu Central Hospital · MWMuhimbili University of Health and Allied Sciences · TZThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: There is a paucity of data on antimicrobial resistance (AMR) in Malawi. Here we present a study of AMR of extended-spectrum β-lactamases-producing Design and Methods: A cross-sectional study was conducted between March and November 2020, involving 403 adult participants aged ≥18 years. Screening for ESBL-E was performed using CHROMagar ESBL medium. Production of ESBLs was confirmed by a combination disk test method. Antimicrobial susceptibility was tested using the agar disk diffusion method in accordance with the Clinical Laboratory Standards Institute's 2019 guidelines. Results: The mean resistance rate of ESBL-E to antimicrobial agents tested was 49.2% (range from 1.4%-92%). The highest resistance rates were observed for trimethoprim-sulfamethoxazole (92%), amoxicillin and ceftriaxone (79%), doxycycline (75%) and gentamicin (72%). Carbapenems (meropenem and imipenem) were highly active against isolates. The overall rate of multi-drug resistant (MDR) ESBL-E was 47%. The highest MDR was found in Conclusions: We found a high resistance rate of ESBL-E isolates to antimicrobial agents; the majority were MDR. Surveillance systems are recommended to monitor AMR in Malawi.

Indexed as

CommunityEnterobacteralesExtended-spectrum β-lactamasesHospitalMalawi

Identifiers

PMID35757822
PMCPMC9216276
OpenAlexW3199737866

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.