Evidence map›Paper›PMID 35757784›Full record

ArticleJID innovations : skin science from molecules to population health2022

Transcriptomic Profiling of Plaque Psoriasis and Cutaneous T-Cell Subsets during Treatment with Secukinumab.

Jared Liu, Hsin-Wen Chang, Robby Grewal, Daniel D Cummins, Audrey Bui, Kristen M Beck, Sahil Sekhon, Di Yan, Zhi-Ming Huang, Timothy H Schmidt and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Pharmaco-Omics in Psoriasis: Paving the Way towards Personalized Medicine.International journal of molecular sciences · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Jared LiuDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Hsin-Wen ChangDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Robby GrewalDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Daniel D CumminsDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Audrey BuiDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Kristen M BeckDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas, USA.
Sahil SekhonDepartment of Dermatology, Howard University, Washington, District of Columbia, USA.
Di YanThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, NYU Langone Health, New York, New York, USA.
Zhi-Ming HuangDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Timothy H SchmidtDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Eric J YangDepartment of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Isabelle M SanchezDepartment of Dermatology, College of Medicine, University of Illinois, Chicago, Illinois, USA.
Mio NakamuraDepartment of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Shrishti BhattaraiDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Quinn ThibodeauxDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Richard AhnInstitute for Quantitative & Computational Biosciences, University of California Los Angeles, Los Angeles, California, USA.
Mariela PauliDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Tina BhutaniDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Michael D RosenblumDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Wilson LiaoDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USBrown University · USHoward University · USMichigan Medicine · USNew York University · USSouthwestern Medical Center · USUniversity of California, Los Angeles · USUniversity of Illinois Chicago · US

Funding

UCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1M
NIAMS NIH HHS T32 AR007175
6 · The paper itself

Abstract

The IL-17A inhibitor secukinumab is efficacious for the treatment of psoriasis. To better understand its mechanism of action, we investigated its impact on psoriatic lesions from 15 patients with moderate-to-severe plaque psoriasis undergoing secukinumab treatment. We characterized the longitudinal transcriptomic changes of whole lesional skin tissue as well as cutaneous CD4

Indexed as

CD8, CD8+ effector T cellDE, differentially expressedFDR, false discovery ratePCA, principal component analysisPGA, Physician’s Global AssessmentRNA-seq, RNA sequencingTeff, effector T cellTh, T helperTreg, regulatory T cell

Identifiers

PMID35757784
PMCPMC9214344
OpenAlexW4226278788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.