ArticleJournal of the American Statistical Association2022
On Genetic Correlation Estimation With Summary Statistics From Genome-Wide Association Studies.
Article in Journal of the American Statistical Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Agnostic polygenic prediction of weight loss after bariatric surgery.JCI insight · 2026Article
- HIGH-DIMENSIONAL STATISTICAL INFERENCE FOR LINKAGE DISEQUILIBRIUM SCORE REGRESSION AND ITS CROSS-ANCESTRY EXTENSIONS.Annals of statistics · 2025Article
- Lifespan investigation of brain volumetric changes associated with substance use disorders.Research square · 2025Article
- Estimation of a genetic Gaussian network using GWAS summary data.Biometrics · 2024Article
- A mediation analysis framework based on variance component to remove genetic confounding effect.Journal of human genetics · 2024Article
- Subgroup identification-based model selection to improve the predictive performance of individualized dosing.Journal of pharmacokinetics and pharmacodynamics · 2024Article
- A PARTIALLY FUNCTIONAL LINEAR REGRESSION FRAMEWORK FOR INTEGRATING GENETIC, IMAGING, AND CLINICAL DATA.The annals of applied statistics · 2024Article
- Estimating trans-ancestry genetic correlation with unbalanced data resources.Journal of the American Statistical Association · 2024Article
- SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits.Genome biology · 2021Article
- Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics.Briefings in bioinformatics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cross-trait polygenic risk score (PRS) method has gained popularity for assessing genetic correlation of complex traits using summary statistics from biobank-scale genome-wide association studies (GWAS). However, empirical evidence has shown a common bias phenomenon that highly significant cross-trait PRS can only account for a very small amount of genetic variance (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.