Evidence map›Paper›PMID 35757757›Full record

ReviewFrontiers in immunology2022

Discovering Immune-Mediated Mechanisms of Gastric Carcinogenesis Through Single-Cell RNA Sequencing.

Stella G Hoft, Michelle D Pherson, Richard J DiPaolo

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stella G HoftDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, United States.
Michelle D PhersonDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, United States.
Richard J DiPaoloDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, United States.
Saint Louis University · US

Funding

Mechanistic Insights of BME mediated inhibition of head and neck cancer growthR01DE025141 · NIDCR · SAINT LOUIS UNIVERSITY · PI Ratna B. Ray · 2015 to 2026
$4.2M
The Role of Inflammation in Regulating Gastritis and Gastric CarcinogenesisR56DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2021 to 2021
$486k
NIDCR NIH HHS R01 DE025141NIDDK NIH HHS R56 DK110406
6 · The paper itself

Abstract

Single-cell RNA sequencing (scRNAseq) technology is still relatively new in the field of gastric cancer immunology but gaining significant traction. This technology now provides unprecedented insights into the intratumoral and intertumoral heterogeneities at the immunological, cellular, and molecular levels. Within the last few years, a volume of publications reported the usefulness of scRNAseq technology in identifying thus far elusive immunological mechanisms that may promote and impede gastric cancer development. These studies analyzed datasets generated from primary human gastric cancer tissues, metastatic ascites fluid from gastric cancer patients, and laboratory-generated data from

Indexed as

Immunity, InnateStomach NeoplasmsCarcinogenesisEndothelial CellsHumansInflammationLymphocytesSequence Analysis, RNATumor MicroenvironmentB cellgastric cancermast cellmyeloid cellsingle cell RNA sequencing (scRNAseq)stromal cellT celltype 2 innate lymphoid cell (ILC2)

Identifiers

PMID35757757
PMCPMC9231461
OpenAlexW4281638159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.