Evidence map›Paper›PMID 35757726›Full record

ArticleFrontiers in immunology2022

mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.

Siawosh K Eskandari, Hazim Allos, Basmah S Al Dulaijan, Gandolina Melhem, Ina Sulkaj, Juliano B Alhaddad, Anis J Saad, Christa Deban, Philip Chu, John Y Choi and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  7. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Siawosh K EskandariTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Hazim AllosTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Basmah S Al DulaijanTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Gandolina MelhemTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Ina SulkajTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Juliano B AlhaddadTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Anis J SaadTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Christa DebanTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Philip ChuTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
John Y ChoiTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Branislav KollarDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Bohdan PomahacDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Leonardo V RiellaTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Stefan P BergerDivision of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jan S F SandersDivision of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Li LiDivision of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jamil R AzziTransplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Harvard University · USBrigham and Women's Hospital · USUniversity Medical Center Groningen · NLBoston Children's Hospital · USJohns Hopkins University · USUniversity of Groningen · NL

Funding

The novel role of the immunoproteasome subunit LMP7 in allo-immunity and T cell exhaustionR01AI134842 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI AZZI, JAMIL · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI134842
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

ApoptosisT-Lymphocytes, RegulatoryAnimalsGranzymesHumansMechanistic Target of Rapamycin Complex 1MiceReceptors, Antigen, T-CellGranzymesMechanistic Target of Rapamycin Complex 1Receptors, Antigen, T-Cellgranzyme Bgrapoptosishuman tregsmTORC1rapamycintreg homeostasis

Identifiers

PMID35757726
PMCPMC9229986
OpenAlexW4281892634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.