Evidence map›Paper›PMID 35757679›Full record

ArticleJournal of clinical and translational science2021

Managing the risks and benefits of clinical research in response to a pandemic.

Patrick A Flume, Elie F Berbari, Laura Viera, Rachel Hess, Janine Higgins, Jennifer Armstrong, Linda Rice, Laura True, Reza Shaker, John B Buse and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Impact of the COVID-19 pandemic on CTSA Clinical Research Centers over 2 years.Journal of clinical and translational science · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Patrick A FlumeDepartments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Elie F BerbariDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Laura VieraClinical Research Support Office, North Carolina Translational and Clinical Sciences Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rachel HessDepartments of Medicine and Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
Janine HigginsDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jennifer ArmstrongDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Linda RiceCenter for Clinical and Translational Science, University of Kentucky, Lexington, KY, USA.
Laura TrueCenter for Clinical and Translational Science, University of Kentucky, Lexington, KY, USA.
Reza ShakerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
John B BuseClinical Research Support Office, North Carolina Translational and Clinical Sciences Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Reynold A PanettieriDepartment of Medicine, Rutgers University, New Brunswick, NJ, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Kentucky · USMayo Clinic in Arizona · USMedical College of Wisconsin · USMedical University of South Carolina · USRutgers, The State University of New Jersey · USUniversity of Utah · US

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
CTSA Coordinating Center for Leading Innovation and Collaboration (CLIC)U24TR002260 · NCATS · UNIVERSITY OF ROCHESTER · PI OSSIP, DEBORAH J, ZAND, MARTIN S · 2017 to 2021
$19.0M
Pilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0M
NCATS NIH HHS U24 TR002260NCATS NIH HHS UL1 TR001436NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR001998NCATS NIH HHS UL1 TR002377NCATS NIH HHS UL1 TR002489NCATS NIH HHS UL1 TR002535NCATS NIH HHS UL1 TR002538NCATS NIH HHS UL1 TR003017NIDDK NIH HHS P30 DK124723NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Introduction: The coronavirus disease 2019 (COVID-19) created major disruptions at academic centers and healthcare systems globally. Clinical and Translational Science Awards (CTSA) fund hubs supported by the National Center for Advancing Translational Sciences provideinfrastructure and leadership for clinical and translational research at manysuch institutions. Methods: We surveyed CTSA hubs and received responses from 94% of them regarding the impact of the pandemic and the processes employed for the protection of research personnel and participants with respect to the conduct of research, specifically for studies unrelated to COVID-19. Results: In this report, we describe the results of the survey findings in the context of the current understanding of disease transmission and mitigation techniques. Conclusions: We reflect on common practices and provide recommendations regarding lessons learned that will be relevant to future pandemics, particularly with regards to staging the cessation and resumption of research activities with an aim to keep the workforce, research participants, and our communities safe in future pandemics.

Indexed as

Clinical researchCOVID-19governancesafetytranslational research

Identifiers

PMID35757679
PMCPMC9201876
OpenAlexW3143856118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.