ReviewComprehensive psychoneuroendocrinology2021
Love and longevity: A Social Dependency Hypothesis.
Review in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- The intertwining of oxytocin's effects on social affiliation and inflammation.Comprehensive psychoneuroendocrinology · 2024Article
- Article
- The gut microbiome and sociability.Frontiers in neuroscience · 2024Review
- Oxytocin and the microbiome.Comprehensive psychoneuroendocrinology · 2023Review
- Brain trust.Comprehensive psychoneuroendocrinology · 2023Review
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Close encounters with oxytocin.Comprehensive psychoneuroendocrinology · 2023Review
- Sex, love and oxytocin: Two metaphors and a molecule.Neuroscience and biobehavioral reviews · 2022Review
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Love and fear: A special issue.Comprehensive psychoneuroendocrinology · 2022Article
- Oxytocin and love: Myths, metaphors and mysteries.Comprehensive psychoneuroendocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mammals, including humans, are reliant for survival and reproduction on adaptations associated with sociality and physiological investment, which can be linked to interactions with their parents or other bonded adult conspecifics. A wide range of evidence in human and non-human mammal species links social behaviors and relationships - including those characterized by what humans call "love" - to positive health and longevity. In light of this evidence, we propose a Social Dependency Hypothesis of Longevity, suggesting that natural selection has favored longer and healthier adult lives in species or in individuals exhibiting enhanced caregiver responsibilities contributing to the success of the next generation. In highlighting cellular, physiological, and behavioral effects of mammalian reproductive hormones, we examine the specific hypothesis that the neuropeptide oxytocin links longevity to the benefits of parental investment and associated relationships. Oxytocin is a pleiotropic molecule with anti-oxidant and anti-inflammatory properties, capable of regulating the hypothalamic-pituitary-adrenal axis, the parasympathetic nervous system and other systems associated with the management of various challenges, including chronic diseases and therefore may be crucial to establishing the maximum longevity potential of a species or an individual.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.