Evidence map›Paper›PMID 35757665›Full record

ReviewComprehensive psychoneuroendocrinology2021

An epigenetic rheostat of experience: DNA methylation of

Joshua S Danoff, Jessica J Connelly, James P Morris, Allison M Perkeybile

Open access · goldAbstract readReview
In one paragraph

Review in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  5. The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025
    Review
  6. Maternal oxytocin administration mitigates nociceptive, social, and epigenetic impairments in adolescent offspring exposed to perinatal trauma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  7. Short-term maternal oxytocin administration may protect against poor outcomes of adverse childhood experiences in the offspring.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023
    Review
  15. Close encounters with oxytocin.Comprehensive psychoneuroendocrinology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Sex, love and oxytocin: Two metaphors and a molecule.Neuroscience and biobehavioral reviews · 2022
    Review
  20. Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joshua S DanoffUniversity of Virginia, Department of Psychology, 102 Gilmer Hall, P.O. Box 400400, Charlottesville, VA, 22904, USA.
Jessica J ConnellyUniversity of Virginia, Department of Psychology, 102 Gilmer Hall, P.O. Box 400400, Charlottesville, VA, 22904, USA.
James P MorrisUniversity of Virginia, Department of Psychology, 102 Gilmer Hall, P.O. Box 400400, Charlottesville, VA, 22904, USA.
Allison M PerkeybileUniversity of Virginia, Department of Psychology, 102 Gilmer Hall, P.O. Box 400400, Charlottesville, VA, 22904, USA.
University of Virginia · US

Funding

Mechanisms of maternal brain changes with birth interventionsR01HD098117 · NICHD · UNIVERSITY OF VIRGINIA · PI JESSICA J CONNELLY, Allison M. Perkeybile · 2019 to 2026
$4.9M
Epigenetic regulation of oxytocin pathways in the maternal brainF32HD092051 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI PERKEYBILE, ALLISON M. · 2018 to 2020
$197k
NICHD NIH HHS F32 HD092051NICHD NIH HHS R01 HD098117
6 · The paper itself

Abstract

Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the

Indexed as

AllostasisDNA methylationEarly life experienceOXTROxytocin receptor

Identifiers

PMID35757665
PMCPMC9216658
OpenAlexW3212944327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.