ArticleFrontiers in neuroscience2022
Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Shared genetic architecture of gray matter deficits in schizophrenia and bipolar disorder: evidence from structural neuroimaging-genetic analyses.Psychological medicine · 2026Pooled it
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Shared neuroimaging and molecular profiles in type 2 diabetes mellitus and major depressive disorder: an integrative analysis of genetic, transcriptomic, and neuroimaging data.Translational psychiatry · 2025Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Cerebellar gray matter volume changes in patients with schizophrenia: A voxel-based meta-analysis.Frontiers in psychiatry · 2022Pooled it
- fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial.BMC medicine · 2026Trial
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- An interpretable TimeMIL framework for fNIRS: differential diagnosis between schizophrenia and bipolar disorder.Frontiers in psychiatry · 2026Article
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- Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder.Psychological medicine · 2025Article
- The prevalence and clinical correlates of severe anxiety symptoms in first-episode drug-naïve schizophrenia: a Chinese population study.BMC psychiatry · 2025Article
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- The impact of the CACNB2 Rs11013860 polymorphism on grey matter volume and brain function in bipolar disorder.BMC psychiatry · 2025Article
- Exploring the Morphological Study of the Brain in Patients with Bipolar Disorder Based on Structural Magnetic Resonance Imaging.Neuropsychiatric disease and treatment · 2025Article
- The Underlying Mechanisms of Comorbid Anxiety and Depression Among Young Women: Evidence From Brain Structure and Hormone.Depression and anxiety · 2025Article
- Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer's disease.GeroScience · 2024Article
- How does the macroenvironment influence brain and behaviour-a review of current status and future perspectives.Molecular psychiatry · 2024Review
- 3-Methoxy-Phencyclidine Induced Psychotic Disorder: A Literature Review and anPharmaceuticals (Basel, Switzerland) · 2024Review
- Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2024Article
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11 authors.
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Abstract
Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are severe psychiatric disorders and share common characteristics not only in clinical symptoms but also in neuroimaging. The purpose of this study was to examine common and specific neuroanatomical features in individuals with these three psychiatric conditions. In this study, 70 patients with SZ, 85 patients with MDD, 42 patients with BD, and 95 healthy controls (HCs) were recruited. Voxel-based morphometry (VBM) analysis was used to explore brain imaging characteristics. Psychopathology was assessed using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Young Mania Rating Scale (YMRS), and the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed using the digit symbol substitution test (DSST), forward-digital span (DS), backward-DS, and semantic fluency. Common reduced gray matter volume (GMV) in the orbitofrontal cortex (OFC) region was found across the SZ, MDD, and BD. Specific reduced GMV of brain regions was also found. For patients with SZ, we found reduced GMV in the frontal lobe, temporal pole, occipital lobe, thalamus, hippocampus, and cerebellum. For patients with MDD, we found reduced GMV in the frontal and temporal lobes, insular cortex, and occipital regions. Patients with BD had reduced GMV in the medial OFC, inferior temporal and fusiform regions, insular cortex, hippocampus, and cerebellum. Furthermore, the OFC GMV was correlated with processing speed as assessed with the DSST across four groups (
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