ArticleFrontiers in neuroscience2022
Male and Female C57BL/6 Mice Respond Differently to Awake Magnetic Resonance Imaging Habituation.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Longitudinal resting-state fMRI of awake mice during habituation: stress, head motion, and functional connectivity.Frontiers in neuroscience · 2026Article
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- Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A low-cost open-source 3D-printed mouse cradle suspension system for awake or anaesthetisedHardwareX · 2025Article
- A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Isoflurane anesthesia alters 31P magnetic resonance spectroscopy markers compared to awake mouse brain.PloS one · 2025Article
- Characterizing vascular function in mouse models of Alzheimer's disease, atherosclerosis, and mixed Alzheimer's and atherosclerosis.Neurophotonics · 2025Article
- The impact of isoflurane anesthesia on brain metabolism in mice: An MRI and electroencephalography study.NMR in biomedicine · 2024Article
- Morphometric Analysis of the Eye by Magnetic Resonance Imaging inBiomedicines · 2024Article
- Open-source versatile 3D-print animal conditioning platform design for in vivo preclinical brain imaging in awake mice and anesthetized mice and rats.Lab animal · 2024Article
- Article
- Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats.Frontiers in neuroscience · 2023Article
- Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.Frontiers in behavioral neuroscience · 2023Article
- Locus coeruleus ablation in mice: protocol optimization, stereology and behavioral impact.Frontiers in cellular neuroscience · 2023Article
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Head holder and cranial window design for sequential magnetic resonance imaging and optical imaging in awake mice.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, preclinical magnetic resonance imaging (MRI) has been performed in anesthetized animals. However, anesthesia has been shown to perturb normal brain function and physiology. Such effects limit our ability to detect subtle physiological alterations in disease models and treatment studies, thus hampering discovery and compromising generality of findings. Therefore, methods for awake animal MRI are needed to study the rodent brain in its natural physiological state, free of anesthetics. Current setups for awake animal MRI rely on restraining systems to avoid animal movement during scanning. To reduce restraint stress, animals are habituated to the scanner environment prior to MRI data collection. To date, however, most awake MRI studies employ male rodents only. This is a fundamental limitation as results obtained may be pertinent only to half of the population. We characterized training and habituation responses of male and female mice to provide improved, sex-dependent training procedures for awake mouse MRI. We recorded heart rate, monitored behavioral responses (body weight and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.