ArticleFrontiers in endocrinology2022
Severe Hyperprolactinemia Promotes Brown Adipose Tissue Whitening and Aggravates High Fat Diet Induced Metabolic Imbalance.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Body composition changes in the postpartum: a systematic review on measurements and predictors.BMC pregnancy and childbirth · 2026Pooled it
- Decoding Adipose Tissue Phenotypic Switching: From Mechanisms to Computational Drug Discovery.Current obesity reports · 2026Review
- From the perspective of prolactin: a view on obesity.Frontiers in endocrinology · 2026Review
- Hyperprolactinemia in children and adolescents: clinical characteristics and etiological spectrum.European journal of pediatrics · 2025Article
- Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice.Nature metabolism · 2025Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- The beneficial and detrimental effects of prolactin hormone on metabolic syndrome: A double-edge sword.Journal of cellular and molecular medicine · 2024Review
- Effect of White Tea on Leptin and Asprosin Levels in Rats Feeding a High-Fat Diet.Life (Basel, Switzerland) · 2024Article
- Article
- Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice.PloS one · 2024Article
- Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.Nutrients · 2023Review
- Clinical characteristics of male prolactinoma patients mainly presenting with severe obesity and the metabolic response to dopamine agonist therapy.Frontiers in endocrinology · 2023Article
- Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta.Frontiers in immunology · 2023Review
- An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin.Frontiers in endocrinology · 2023Review
- The interplay between prolactin and cardiovascular disease.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association of high serum prolactin and increased body weight is positive but controversial, therefore we hypothesized that additional factors such as diets and the impact of prolactin on brown adipose tissue may condition its metabolic effects. Methods: We used LacDrd2KO females with lifelong severe hyperprolactinemia due dopamine-D2 receptor deletion from lactotropes, and slow onset of metabolic disturbances, and compared them to their respective controls Results: Hyperprolactinemic mice had increased food intake and binge eating behavior. Metabolic effects induced by a HFD were exacerbated in lacDrd2KO mice. Hyperprolactinemia aggravated HFD-induced body weight gain and glucose intolerance. In brown adipose tissue pronounced cellular Conclusions: Pathological hyperprolactinemia has a strong impact in brown adipose tissue, lowering thermogenic markers and evoking tissue whitening. Furthermore, it modifies lipogenic markers in subcutaneous white adipose, and aggravates HFD-induced glucose intolerance and
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Registered trials
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