Evidence map›Paper›PMID 35757409›Full record

ArticleFrontiers in endocrinology2022

A Novel Somatic Mutation of

Chi-Shin Tseng, Kang-Yung Peng, Shuo-Meng Wang, Yao-Chou Tsai, Kuo-How Huang, Wei-Chou Lin, Ya-Hui Hu, Vin-Cent Wu, Jeff S Chueh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chi-Shin TsengGraduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Kang-Yung PengDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shuo-Meng WangDepartment of Urology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Yao-Chou TsaiDivision of Urology, Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Kuo-How HuangDepartment of Urology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Wei-Chou LinDepartment of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Ya-Hui HuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, Taipei, Taiwan.
Vin-Cent WuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jeff S ChuehDepartment of Urology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
National Taiwan University Hospital · TWTaipei Tzu Chi Hospital · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Somatic mutations for excess aldosterone production have been frequently identified as important roles in the pathogenesis of unilateral primary hyperaldosteronism (uPA). Although Objective: To identify novel somatic Methods: We applied a customized and targeted gene panel next-generation sequencing approach to detect mutations from the uPA cohort in Taiwan Primary Aldosteronism Investigation study group. Information from pre-diagnostic to postoperative data was collected, including past history, medications, blood pressure readings, biochemical data, and image studies. The functional role of the variant was confirmed by Results: We identified a novel somatic Conclusions: The somatic mutation of

Indexed as

Calcium Channels, T-TypeHyperaldosteronismAdrenalectomyAldosteroneCytochrome P-450 CYP11B2HumansMutationAldosteroneCACNA1H protein, humanCalcium Channels, T-TypeCytochrome P-450 CYP11B2adrenalectomyaldosterone producing adenomaCACNA1Hprimary aldosteronismV1937M mutation

Identifiers

PMID35757409
PMCPMC9218183
OpenAlexW4281707009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.