Evidence map›Paper›PMID 35757368›Full record

ArticleComprehensive psychoneuroendocrinology2021

Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice.

Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Thiago Ângelo Smaniotto, Paloma Taborda Birmann, Beatriz Vieira, Mariana Souza Sonego, Fabiana Kömmling Seixas, Tiago Collares, Eder João Lenardão and 1 more

Open access · goldAbstract read
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Physiological Benefits of Novel Selenium Delivery via Nanoparticles.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Recent Advances in Light-Induced Selenylation.ACS organic & inorganic Au · 2022
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Angela Maria CasarilTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Darling de Andrade LourençoTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Micaela DominguesTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Thiago Ângelo SmaniottoTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Paloma Taborda BirmannTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Beatriz VieiraCenter of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil.
Mariana Souza SonegoTechnological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group, Laboratory of Cancer Biotechnology, Federal University of Pelotas, Pelotas, RS, Brazil.
Fabiana Kömmling SeixasTechnological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group, Laboratory of Cancer Biotechnology, Federal University of Pelotas, Pelotas, RS, Brazil.
Tiago CollaresTechnological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group, Laboratory of Cancer Biotechnology, Federal University of Pelotas, Pelotas, RS, Brazil.
Eder João LenardãoCenter of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil.
Lucielli SavegnagoTechnological Development Center, Division of Biotechnology, Nanobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Universidade Federal de Pelotas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the severity and the high prevalence of depression and anxiety and the efforts that have been done to improve their treatment, the available pharmacotherapy still has several limitations. Therefore, the investigation of novel agents and the characterization of the molecular signaling pathways underlying their effects are needed. The organoselenium compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1

Indexed as

AntidepressantAnxiolyticCorticosteroneHPA axisOrganoseleniumPI3K/mTOR

Identifiers

PMID35757368
PMCPMC9216694
OpenAlexW3142137090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.