Evidence map›Paper›PMID 35757366›Full record

ArticleComprehensive psychoneuroendocrinology2021

Differential stress response to psychological and physical stressors in children using spatial versus response-dependent navigation strategies.

Greg L West, Vanessa Kurdi, Celine Fouquet, Russell Schachar, Michel Boivin, Paul Hastings, Philippe Robaey, Veronique D Bohbot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Greg L WestDepartment of Psychology, University of Montreal, Montreal, QC, Canada.
Vanessa KurdiDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, QC, Canada.
Celine FouquetDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, QC, Canada.
Russell SchacharHospital for Sick Children, Toronto, ON, Canada.
Michel BoivinDept. of Psychology, Laval University, Quebec, QC, Canada.
Paul HastingsDepartment of Psychology, University of California Davis, CA, United States.
Philippe RobaeyDeptartment of Psychiatry, Faculty of Medicine, University of Ottawa, Canada.
Veronique D BohbotDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, QC, Canada.
Douglas Mental Health University Institute · CAHospital for Sick Children · CAUniversité de Montréal · CAUniversité Laval · CAUniversity of California, Davis · USUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous work from our lab has shown that basal cortisol levels are different between healthy young adults who spontaneously use caudate nucleus-dependent response strategies compared to young adults who use hippocampus-dependent spatial navigation strategies. Young adults who use caudate nucleus dependent strategies display lower basal cortisol levels compared to those who use hippocampus-dependent strategies. In the current study, we assessed navigation strategies in children using a virtual navigation task and measured cortisol at baseline as well as cortisol reactivity to both a psychological and to a physical stressor. Replicating what is observed in adults, we found that children who used caudate nucleus-dependent navigation strategies displayed lower cortisol levels at baseline compared to those who used hippocampus-dependent strategies. The psychological stressor, knowledge that a blood draw would be performed by a nurse, caused a significant increase in cortisol uniquely in response learners. The physical stressor, the actual blood draw, produced a significant increase in cortisol amongst spatial learners that was then comparable to levels observed in response learners. Lower baseline cortisol and higher cortisol psychological stress response observed amongst children who used response strategies may therefore reflect early biological changes during development which may have an impact later in life when considering risk for neuropsychiatric disorders.

Indexed as

Caudate nucleusCortisolDevelopmentHippocampusNavigational strategiesStress response

Identifiers

PMID35757366
PMCPMC9216353
OpenAlexW3134047074

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.