ArticleComprehensive psychoneuroendocrinology2021
Testosterone and specific symptoms of depression: Evidence from NHANES 2011-2016.
Article in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Exploring the Causal Relationship Between Sex Hormones and Depression by Means of Two-Sample Mendelian Randomization Analysis.Actas espanolas de psiquiatria · 2026Article
- Sexual functioning, mental health and quality of life in 46,XX male: a case report.Journal of medical case reports · 2026Article
- Testosterone Concentration and Incident Depression in Older Men: A Longitudinal Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Salivary hormones in depression: the future in diagnosis and treatment.Annals of general psychiatry · 2025Review
- Correlation between low testosterone levels and the risk of osteoarthritis: a cross-sectional analysis of NHANES data (2011-2016).BMC musculoskeletal disorders · 2025Article
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- Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems.Frontiers in psychology · 2024Review
- No evidence for relationship between paternal post-partum depressive symptoms and testosterone or cortisol in first-time fathers.Frontiers in psychology · 2024Article
- Repeated restraint stress induced neurobehavioral and sexual hormone disorders in male rats.AIMS neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone is one possible biomarker for depression risk among men and women. Both high and low levels of testosterone have been associated with depression, at least among men. Testosterone may be associated only with specific symptoms of depression, which might help to explain inconsistencies in previous results. We examined the cross-sectional associations between total testosterone and the specific symptoms of depression using pooled data across three cycles of NHANES (2011-2012, 2013-2014, and 2015-2016). The sample included 4253 men and 5102 women. Testosterone was modelled as 1) a dichotomous (low testosterone cut-off <300 ng/dL for men and 15 ng/dL for women) and 2) a continuous variable using cubic splines. In men, very low testosterone was weakly associated with problems with appetite, whereas very high testosterone was associated with sleep problems and weakly associated with tiredness. There were no consistent symptom-specific associations among women. These findings provide only suggestive evidence for symptom-specific associations between testosterone and depression, mainly related to somatic complaints. Further data are needed to assess the reliability of these associations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.