Evidence map›Paper›PMID 35757337›Full record

ArticleFrontiers in cardiovascular medicine2022

An Atypical Anomalous Aortic Origin of the Left Coronary Artery With Intra-Arterial Wall Course Pretending a Normal Migration on Imaging Screening: A Case Report.

Fan Hu, Xinyue Wang, Jiaojiao Wan, Yifei Li, Tao Wang, Kaiyu Zhou, Xiaoqing Shi, Zhongqiang Liu, Jie Fang, Yimin Hua

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fan HuKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xinyue WangKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jiaojiao WanKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yifei LiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Tao WangKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Kaiyu ZhouKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xiaoqing ShiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhongqiang LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jie FangKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yimin HuaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Oral Diseases, Department of Pediatrics, National Clinical Research Center for Oral Diseases, West China Second University Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Sichuan University · CNState Key Laboratory of Oral Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: An anomalous aortic origin of a coronary artery (AAOCA) has been considered as a dominant cause of sudden cardiac death (SCD) among young age children. Therefore, it is critical to identify AAOCA timely to avoid lethal events. Recently, accumulating cases of right or left coronary arteries originating from inappropriate locations at the sinus of Valsalva have been identified. Here, we report a rare case of AAOCA with an intra-arterial wall course pretending normal migration on imaging screening in a patient who suffered from syncope. Case summary: A 7-year-old male without a previous history of cardiovascular and cerebrovascular diseases suddenly suffered from sharp chest pain and syncope after intensive exercise. The electrocardiogram showed that the ST segment of multiple leads was depressed by more than 0.05 mV, and biomarkers indicated severe myocardial injuries. The left ventricular ejection fraction (LVEF) decreased dramatically to 23%. Fulminant myocarditis and cardiomyopathy were therefore excluded. However, a relatively normal coronary artery origin, which arose from the left coronary sinus, presented on echocardiography and cardiac CT angiography (CTA). It is difficult to draw an association between severe clinical manifestations and slight malformations on echocardiography and CTA. Furthermore, selective coronary angiography revealed that an anomalous left coronary artery arose from the superior margin of the inappropriate sinus, developed an intramural wall course and finally exits the left sinus of Valsalva and migrated between the aorta and the pulmonary artery, which induced severe myocardial infarction during exercise. Then, the patient received surgical correction with a modified unroofing procedure. After 2 months of intensive treatment, the patient was discharged and remained asymptomatic through 18 months of follow-up. Conclusion: AAOCA, especially anomalous left coronary artery (ALCA), represents a major potential risk of SCD. We reported an atypical manifestation of ALCA arising from the inappropriate sinus of Valsalva and merging into the intra-arterial wall to develop a strange course and then sprout between the aorta and the pulmonary artery. The diversity of AAOCA might present as a relatively normal course under non-invasive radiological imaging scanning.

Indexed as

anomalous aortic origin of a coronary arterycase reportintra-arterial wall coursenon-coronary sinus of valsalvasyncope

Identifiers

PMID35757337
PMCPMC9222707
OpenAlexW4281771708

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.