Evidence map›Paper›PMID 35757254›Full record

ReviewFrontiers in nutrition2022

Recent Advances on the Function and Purification of Milk Exosomes: A Review.

Xiaoping Li, Lan Su, Xinling Zhang, Qi Chen, Ying Wang, Zhenwei Shen, Tian Zhong, Ling Wang, Ying Xiao, Xiao Feng and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  7. Article
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  11. Article
  12. Article
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  15. Article
  16. Review
  17. Review
  18. Review
  19. Exosomes in Mastitis-Research Status, Opportunities, and Challenges.Animals : an open access journal from MDPI · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoping LiFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Lan SuShulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Xinling ZhangShulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Qi ChenShulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Ying WangShulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Zhenwei ShenShulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Tian ZhongFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Ling WangFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Ying XiaoFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Xiao FengCollege of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, China.
Xi YuFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nano-scale extracellular vesicles, which can be used as drug carriers, tumor treatment, intestinal development and immune regulator. That is why it has great potential in pharmacy, functional foods, nutritional supplements, especially those for infants, postoperative patients, chemotherapy patients and the elderly. In addition, abnormal exosome level is also related to diseases such as cardiovascular diseases, tumor, diabetes, neurodegenerative and autoimmune diseases, as well as infectious diseases. Despite its high biological significance, pharmaceutical and nutritional value, the low abundancy of exosomes in milk is one of the bottlenecks restricting its in-depth research and real-life application. At present, there is no unified standard for the extraction of breast milk exosomes. Therefore, choosing the proper extraction method is very critical for its subsequent research and development. Based on this, this paper reviewed the purification techniques, the function and the possible applications of milk exosomes based on 47 latest references. Humble advices on future directions, prospects on new ideas and methods which are useful for the study of exosomes are proposed at the end of the paper as well.

Indexed as

biological functionclinical applicationexosomesmilkpurification technique

Identifiers

PMID35757254
PMCPMC9219579

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.