Evidence map›Paper›PMID 35757228›Full record

ArticleFrontiers in psychiatry2022

Sex Differences in Bipolar Disorders: Impact on Psychopathological Features and Treatment Response.

Giulia Menculini, Luca Steardo, Tiziana Sciarma, Martina D'Angelo, Laura Lanza, Gianmarco Cinesi, Federica Cirimbilli, Patrizia Moretti, Norma Verdolini, Pasquale De Fazio and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  11. Patterns of lithium exposure and mortality in bipolar disorder: A population-based cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giulia MenculiniSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Luca SteardoPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Tiziana SciarmaSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Martina D'AngeloPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Laura LanzaSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Gianmarco CinesiSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Federica CirimbilliSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Patrizia MorettiSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Norma VerdoliniLocal Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Perugia, Italy.
Pasquale De FazioPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Alfonso TortorellaSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
University of Perugia · ITMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sex differences were demonstrated in bipolar disorders (BD) concerning epidemiological, clinical, and psychopathological characteristics, but consensus is lacking. Moreover, data concerning the influence of sex on treatment response in BD is contrasting. The present cross-sectional study aimed to analyze sex differences in a population of BD subjects, with specific focus on psychopathological features and treatment response. Materials and Methods: Subjects diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th version (DSM-5) were recruited. Socio-demographic and clinical characteristics were collected. The Hamilton Rating Scale for Depression, the Mania Rating Scale (MRS), the brief version of the Temperament Evaluation of Memphis, Pisa and San Diego-Münster version (briefTEMPS-M), and the Barratt Impulsiveness Scale-11 items (BIS-11) were used for psychopathological assessment. Treatment response was appraised with the Alda Scale. We performed bivariate analyses to compare socio-demographic, clinical, and psychopathological characteristics between men and women ( Results: Among the recruited 219 BD subjects, 119 (54.3%) were females. Women had a lower scholarity ( Conclusions: The clinical presentation of BD may differ depending on sex. The severity of BD should not be neglected among women, who may also display worse treatment response to anticonvulsants.

Indexed as

bipolar disordersmood stabilizerspsychopathologysex differencestreatment response

Identifiers

PMID35757228
PMCPMC9226371
OpenAlexW4281607110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.