Evidence map›Paper›PMID 35757201›Full record

ArticleFrontiers in psychiatry2022

Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naïve Schizophrenia.

Yuxuan Wu, Xiangdong Du, Ruchang Yang, Yan Yue, Ruijie Peng, Siqi Wu, Haitao Wang, Yue Zhou, Xiaojia Fang, Nian Yuan and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Yuxuan WuSuzhou Medical College of Soochow University, Suzhou, China.
Xiangdong DuSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Ruchang YangSuzhou Medical College of Soochow University, Suzhou, China.
Yan YueSuzhou Medical College of Soochow University, Suzhou, China.
Ruijie PengSuzhou Medical College of Soochow University, Suzhou, China.
Siqi WuSchool of Psychology and Mental Health, North China University of Science and Technology, Tangshan, China.
Haitao WangSchool of Psychology and Mental Health, North China University of Science and Technology, Tangshan, China.
Yue ZhouSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Xiaojia FangSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Nian YuanSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Ronghua LiSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Jun ZhangSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Siyun ZouSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Xueli ZhaoSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Xiaoli LyuSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Zhe LiSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Xiaobin ZhangSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Xiangyang ZhangCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Soochow University · CNNorth China University of Science and Technology · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have revealed that brain-derived neurotrophic factor (BDNF) levels are inversely associated with the severity of depressive symptoms. In addition, serum BDNF levels tend to increase with improvement in depressive symptoms. There is also evidence that BDNF has a possible role in the pathophysiology of schizophrenia. Therefore, the purpose of this study was to determine whether BDNF levels correlated with depressive symptoms in patients with first-episode and drug-naïve (FEDN) schizophrenia. In this study, 90 patients with FEDN schizophrenia and 60 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the 17-item Hamilton Depression Scale (HAMD-17) were used to gage psychopathological and depressive symptoms, respectively. All participants had their BDNF levels measured using a sandwich enzyme-linked immunosorbent test. Serum BDNF levels were lower in patients with FEDN schizophrenia compared with healthy controls. Moreover, patients with depressive symptoms exhibited a higher PANSS total score and a higher general psychopathology score than those without depressive symptoms (

Indexed as

brain-derived neurotrophic factordepressive symptomsfirst episode psychosisschizophreniaserum

Identifiers

PMID35757201
PMCPMC9218218
OpenAlexW4282051943

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.