Evidence map›Paper›PMID 35757148›Full record

ArticleInternational journal of cardiology. Heart & vasculature2022

Better prediction of stroke in atrial fibrillation with incorporation of cancer in CHA

Brandon Bungo, Pulkit Chaudhury, Michael Arustamyan, Rishi Rikhi, Muzna Hussain, Patrick Collier, Mohamed Kanj, Alok A Khorana, Amgad Mentias, Rohit Moudgil

Open access · goldAbstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Anticoagulant therapy in patients with cancer and thrombocytopenia.Journal of thrombosis and thrombolysis · 2025
    Review
  5. The B-SCancers · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2024
    Article
  10. Performance of CHAEuropean heart journal open · 2024
    Article
  11. Article
  12. Cancer and arterial thrombosis: therapeutic options.Research and practice in thrombosis and haemostasis · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Revisiting important issues in cancer and atrial fibrillation.Research and practice in thrombosis and haemostasis · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Brandon BungoSection of Clinical Cardiology, United States.
Pulkit ChaudhurySection of Vascular Medicine, United States.
Michael ArustamyanSection of Clinical Cardiology, United States.
Rishi RikhiSection of Clinical Cardiology, United States.
Muzna HussainSection of Cardiovascular Imaging, United States.
Patrick CollierSection of Cardiovascular Imaging, United States.
Mohamed KanjSection of Electrophysiology, Department of Cardiovascular Medicine, Heart and Vascular Institute, United States.
Alok A KhoranaTaussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic Foundation, United States.
Amgad MentiasSection of Clinical Cardiology, United States.
Rohit MoudgilSection of Clinical Cardiology, United States.
Cleveland Clinic · USCenter for Vascular Biology Research · US

Funding

Novel approaches to improve prediction of cancer-associated thrombosisU01HL143402 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KHORANA, ALOK A, MCCRAE, KEITH R. · 2018 to 2022
$4.7M
NHLBI NIH HHS U01 HL143402
6 · The paper itself

Abstract

Introduction: Atrial fibrillation (AF) is associated with an increased risk of stroke. Despite evidence linking cancer and thrombosis, cancer is not part of the CHA Hypothesis: Cancer is an independent risk factor for thromboembolic stroke in patients with AF. Method: The SEER database was utilized to identify patients with lung, colon, breast, and prostate cancers with AF and no prior diagnosis of stroke and. compared to controls within the dataset. The primary endpoint was rates of stroke per 100 person-years. Cox regression modeling and a nested model comparing CHA Results: A total of 101,185 patients were included in the analysis, with 48,242 in the Cancer and 52,943 in the Non-cancer Group. Stroke rate per 100 person-years was significantly higher in the Cancer Group. The CHA Conclusion: Cancers increase the risk of stroke in patients with AF. Consideration should be given to the addition of cancer to the clinical scoring system.

Indexed as

Atrial fibrillationCancerCHADs2VAsc ScoreStroke

Identifiers

PMID35757148
PMCPMC9218829
OpenAlexW4283170995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.