Evidence map›Paper›PMID 35757105›Full record

ArticleMediators of inflammation2022

Shaoyao-Gancao Decoction Promoted Microglia M2 Polarization via the IL-13-Mediated JAK2/STAT6 Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury.

Juanjuan Lu, Jie Wang, Long Yu, Rong Cui, Ying Zhang, Hanqing Ding, Guofeng Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Juanjuan LuDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai 200031, China.ORCID https://orcid.org/0000-0003-1463-2917
Jie WangDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai 200031, China.ORCID https://orcid.org/0000-0002-7594-9427
Long YuDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai 200031, China.ORCID https://orcid.org/0000-0001-6587-003X
Rong CuiDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai 200031, China.ORCID https://orcid.org/0000-0002-6434-6444
Ying ZhangDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai 200031, China.ORCID https://orcid.org/0000-0001-9859-6698
Hanqing DingAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID https://orcid.org/0000-0003-0795-6585
Guofeng YanSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-2328-7916
Shanghai Xuhui Central Hospital · CNShanghai Jiao Tong University · CNShanghai University of Sport · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia in the penumbra shifted from M2 to M1 phenotype between 3 and 5 days after cerebral ischemia-reperfusion, which promoted local inflammation and injury. Shaoyao-Gancao Decoction (SGD) has been found to result in a significant upregulation of IL-13 in the penumbra, which has been shown to induce polarization of M2 microglia. There was thus a hypothesis that SGD could exert an anti-inflammatory and neuroprotective effect by activating IL-13 to induce microglia polarization towards M2 phenotype, and the purpose of this study was to explore the influence of SGD on microglia phenotype switching and its possible mechanism. Rats who received middle cerebral artery occlusion surgery (MCAO) were treated with SGD for 3 or 6 days, to investigate the therapeutic effect and the underlying mechanism of SGD for cerebral ischemia-reperfusion injury (CI/RP). The results indicated that SGD improved neurobehavioral scores and reduced apoptosis. Furthermore, SGD significantly decreased M1 microglia and M1-like markers, but increased M2 microglia and M2 markers. Moreover, higher levels of IL-13 and ratios of p-JAK2/JAK2 and p-STAT6/STAT6 were found in the SGD group compared to the MCAO. In conclusion, it was verified that SGD prevented injury by driving microglia phenotypic switching from M1 to M2, probably via IL-13 and its downstream JAK2-STAT6 pathway. Given that no further validation tests were included in this study, it is necessary to conduct more experiments to confirm the reliability of the above results.

Indexed as

Brain IschemiaDrugs, Chinese HerbalGlycyrrhizaMicrogliaReperfusion InjurySTAT6 Transcription FactorAnimalsInfarction, Middle Cerebral ArteryInterleukin-13Janus Kinase 2RatsReproducibility of ResultsSignal TransductionDrugs, Chinese Herbalglycyrrhizae radix et rhizomaInterleukin-13Jak2 protein, ratJanus Kinase 2STAT6 Transcription Factor

Identifiers

PMID35757105
PMCPMC9232306
OpenAlexW4283020469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.