Evidence map›Paper›PMID 35757074›Full record

ArticleIJID regions2022

Human herpes simplex virus-6 (HHV-6) detection and seroprevalence among Qatari nationals and immigrants residing in Qatar.

Duaa W Al-Sadeq, Hadeel T Zedan, Nader Aldewik, Alaa Elkhider, Asalet Hicazi, Nadin Younes, Houssein H Ayoub, Laith Abu Raddad, Hadi M Yassine, Gheyath K Nasrallah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJID regions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Duaa W Al-SadeqBiomedical Research Centre, QU Health, Qatar University, Doha, Qatar.
Hadeel T ZedanBiomedical Research Centre, QU Health, Qatar University, Doha, Qatar.
Nader AldewikClinical and Metabolic Genetics Section, Paediatrics Department, Hamad General Hospital, Women's Wellness and Research Centre, Interim Translational Research Institute, Hamad Medical Corporation, College of Health and Life Science, Hamad Bin Khalifa University, Doha, Qatar.
Alaa ElkhiderDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Asalet HicaziDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Nadin YounesDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Houssein H AyoubMathematics Programme, Department of Mathematics, Statistics and Physics, College of Arts and Sciences, Qatar University, Doha, Qatar.
Laith Abu RaddadInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
Hadi M YassineBiomedical Research Centre, QU Health, Qatar University, Doha, Qatar.
Gheyath K NasrallahBiomedical Research Centre, QU Health, Qatar University, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human herpes simplex virus-6 (HHV-6) is the causative agent of exanthema subitum. Transmission mainly occurs through salivary secretions, yet blood transfusions and organ transplantations have also been reported as routes of transmission. Studies of seroprevalence of HHV-6 in the Middle East and North Africa (MENA) region and other parts of Asia are scarce. As such, this study aimed to estimate the seroprevalence of HHV-6 among healthy blood donors in Qatar. Methods: In total, 620 healthy blood donors from different nationalities residing in Qatar, mainly from the MENA region and Southeast Asia, were tested using a commercial anti-HHV-6 immunoglobulin G (IgG) enzyme-linked immunosorbent assay kit. In addition, HHV-6 DNA from randomly selected samples was tested and quantified using quantitative reverse transcriptase polymerase chain reaction. Results: Anti-HHV-6 IgG was detected in 71.7% (445/620) [95% confidence interval (CI) 68.2-75.3%] of the tested samples, while 24.3% (61/251) (95% CI 20.0-29.6%) had detectable HHV-6 viraemia. Only 22.5% of individuals with positive IgG status had detectable HHV-6 DNA in their blood, indicating a weak association between viraemia and IgG positivity (P=0.08). Furthermore, no significant difference was associated between HHV-6 viraemia and demographic characteristics, except for nationality. Conclusion: The seroprevalence of HHV-6 in Qatar was found to be similar to rates reported in other parts of the world.

Indexed as

Blood donorsHHV-6SeroprevalenceTransfusionViraemia

Identifiers

PMID35757074
PMCPMC9216376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.