ArticleComprehensive psychoneuroendocrinology2021
The effects of puberty and its hormones on subcortical brain development.
Article in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan.Nature communications · 2026Article
- Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study.Human brain mapping · 2025Article
- Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure.Developmental cognitive neuroscience · 2025Article
- Impact of Sex and Salivary Dehydroepiandrosterone on the Association Between Testosterone and Emotion Dysregulation.Developmental psychobiology · 2025Article
- Shorter weeknight sleep duration mediates the relationship between earlier adrenarche and depressed mood in adolescents.Journal of affective disorders · 2025Article
- Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- Pubertal hormones and mental health problems in children and adolescents: a systematic review of population-based studies.EClinicalMedicine · 2024Review
- Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Application of eye and hand interventions in brain magnetic resonance imaging of young children.Heliyon · 2024Article
- Sex, gender diversity, and brain structure in early adolescence.Human brain mapping · 2024Article
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
- Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events.Journal of mental health & clinical psychology · 2024Article
- Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology.Hormones and behavior · 2024Article
- Profiling intra- and inter-individual differences in brain development across early adolescence.NeuroImage · 2023Article
- Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.Developmental cognitive neuroscience · 2022Article
- The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan.Wiley interdisciplinary reviews. Cognitive scienceReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty triggers a period of structural "re-organization" in the brain, when rising hormone levels act via receptors to influence morphology. However, our understanding of these neuroendocrine processes in humans remains poor. As such, the current longitudinal study characterized development of the human subcortex during puberty, including changes in relation to pubertal (Tanner) stage and hormone (testosterone, dehydroepiandrosterone [DHEA]) levels. Beyond normative group-level patterns of development, we also examined whether individual differences in the rate of pubertal maturation (i.e., "pubertal/hormonal tempo") were associated with variations in subcortical trajectories. Participants (N = 192; scans = 366) completed up to three waves of MRI assessments between 8.5 and 14.5 years of age. Parents completed questionnaire assessments of pubertal stage at each wave, and adolescents provided hormone samples on a subset of waves. Generalized additive mixture models were used to characterize trajectories of subcortical development. Results showed that development of most subcortical structures was related to pubertal stage, although findings were mostly non-significant when controlling for age. Testosterone and DHEA levels were related to development of the amygdala, hippocampus and pallidum in both sexes, and findings in the amygdala remained significant when controlling for age. Additionally, we found that variability in hormonal (specifically testosterone) tempo was related to right hippocampal development in males, with an accelerated pattern of hippocampal development in those with greater increases in testosterone levels. Overall, our findings suggest prominent hormonal influences on the amygdala and hippocampus, consistent with the prevalence of androgen and estrogen receptors in these regions. We speculate that these findings are most likely reflective of the important role of adrenarcheal processes on adolescent brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.