Evidence map›Paper›PMID 35757015›Full record

ArticleAnalytical cellular pathology (Amsterdam)2022

"Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)" Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma.

Carl Randall Harrell, Dragica Pavlovic, Dragana Miloradovic, Milica Dimitrijevic Stojanovic, Valentin Djonov, Vladislav Volarevic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carl Randall HarrellRegenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, FL 34684, USA.ORCID https://orcid.org/0000-0002-5906-9198
Dragica PavlovicDepartment of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.ORCID https://orcid.org/0000-0002-1948-5365
Dragana MiloradovicDepartment of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.ORCID https://orcid.org/0000-0003-2343-3979
Milica Dimitrijevic StojanovicDepartment of Pathology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.ORCID https://orcid.org/0000-0001-6492-7305
Valentin DjonovInstitute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0002-5062-1169
Vladislav VolarevicDepartment of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.ORCID https://orcid.org/0000-0001-5948-9902
University of Kragujevac · RSUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is considered refractory to immunotherapy. Accordingly, there is an urgent need for the therapeutic use of new immunostimulatory agents which would enhance antitumor immune response against breast cancer cells. "Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)" is a biological product whose activity is based on chemokines and cytokines that modulate homing and phenotype of immune cells. d-MAPPS contains high concentration of dendritic cell (DC) and T cell-attracting chemokine CXCL16 and potent T cell-activating cytokine IL-27 which enhance DC:T cell cross-talk in inflamed tissues. Herewith, we used 4T1 murine model of breast cancer to analyze d-MAPPS-dependent enhancement of T cell-driven antitumor immunity. 4T1+d-MAPPS-treated mice showed delayed mammary tumor appearance compared to 4T1+saline-treated animals. d-MAPPS significantly reduced tumor weight and volume and improved survival of 4T1-treated mice. Significantly increased concentration of CXCL16, IL-27, IFN-

Indexed as

Breast NeoplasmsCarcinomaHematopoietic Stem Cell TransplantationInterleukin-27AnimalsCytokinesDendritic CellsFemaleHumansImmunityInterleukin-10Interleukin-17MiceMice, Inbred BALB CParacrine CommunicationTransforming Growth Factor betaCytokinesInterleukin-10Interleukin-17Interleukin-27Transforming Growth Factor beta

Identifiers

PMID35757015
PMCPMC9217617
OpenAlexW4282966948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.