Evidence map›Paper›PMID 35756922›Full record

ArticleFrontiers in neurology2022

Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease.

Jaya Bagaria, Yeonsil Moon, Eva Bagyinszky, Kyu Hwan Shim, Seong Soo A An, SangYun Kim, Seol Heui Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Discovery of a Missense Mutation (Q222K) of theJournal of Alzheimer's disease reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jaya BagariaDepartment of Bionanotechnology, Gachon University, Seongnam-si, South Korea.
Yeonsil MoonDepartment of Neurology, Konkuk University School of Medicine and Konkuk University Medical Center, Seoul, South Korea.
Eva BagyinszkyDepartment of Industrial and Environmental Engineering, Graduate School of Environment, Gachon University, Seongnam, South Korea.
Kyu Hwan ShimDepartment of Bionanotechnology, Gachon University, Seongnam-si, South Korea.
Seong Soo A AnDepartment of Bionanotechnology, Gachon University, Seongnam-si, South Korea.
SangYun KimDepartment of Neurology, Seoul National University College of Medicine and Seoul National University Budang Hospital, Seongnam-si, South Korea.
Seol Heui HanDepartment of Neurology, Konkuk University School of Medicine and Konkuk University Medical Center, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein (APOE) is implicated and verified as the main risk factor for early-onset Alzheimer's disease (AD). APOE is a protein that binds to lipids and is involved in cholesterol stability. Our paper reports a case of a sporadic early-onset AD (sEOAD) patient of a 54-year-old Korean man, where a novel

Indexed as

APOEearly-onset Alzheimer's diseaseLeu159ProLow-Density Lipoprotein Receptor (LDLR)novel mutationWhole Exome Sequence (WES) analysis

Identifiers

PMID35756922
PMCPMC9226417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.