Evidence map›Paper›PMID 35756903›Full record

ArticlePhysical review. X

Protein concentration fluctuations in the high expression regime: Taylor's law and its mechanistic origin.

Alberto Stefano Sassi, Mayra Garcia-Alcala, Maximino Aldana, Yuhai Tu

Open access · goldAbstract read
In one paragraph

Article in Physical review. X. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Emergent Homeostasis and Degeneracy From Multi-Dimensional Attractors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Continuous partitioning of neuronal variability.bioRxiv : the preprint server for biology · 2025
    Article
  4. Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alberto Stefano SassiIBM T.J. Watson Research Center, Yorktown Heights, NY 10598, U.S.A.
Mayra Garcia-AlcalaDepartment of Molecular and Cellular Biology, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Maximino AldanaInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, México.
Yuhai TuIBM T.J. Watson Research Center, Yorktown Heights, NY 10598, U.S.A.
Harvard University · USUniversidad Autónoma de la Ciudad de México · MX

Funding

Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological SystemsR35GM131734 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2019 to 2024
$1.8M
Noise, memory, and adaptation in the flagellum system in E.coli.R01GM134275 · NIGMS · HARVARD UNIVERSITY · PI CLUZEL, PHILIPPE · 2019 to 2020
$642k
NIGMS NIH HHS R01 GM134275NIGMS NIH HHS R35 GM131734
6 · The paper itself

Abstract

Protein concentration in a living cell fluctuates over time due to noise in growth and division processes. In the high expression regime, variance of the protein concentration in a cell was found to scale with the square of the mean, which belongs to a general phenomenon called Taylor's law (TL). To understand the origin for these fluctuations, we measured protein concentration dynamics in single

Identifiers

PMID35756903
PMCPMC9233241
OpenAlexW4221079622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.