Evidence map›Paper›PMID 35756893›Full record

ArticleiScience2022

Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways.

Daniel Richard, Pushpanathan Muthuirulan, Jennifer Aguiar, Andrew C Doxey, Arinjay Banerjee, Karen Mossman, Jeremy Hirota, Terence D Capellini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  8. IL-22-ActivatedCells · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Daniel RichardDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Pushpanathan MuthuirulanDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Jennifer AguiarDepartment of Biology, University of Waterloo, Waterloo, ON N2L3G1, Canada.
Andrew C DoxeyDepartment of Biology, University of Waterloo, Waterloo, ON N2L3G1, Canada.
Arinjay BanerjeeDepartment of Biology, University of Waterloo, Waterloo, ON N2L3G1, Canada.
Karen MossmanDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Jeremy HirotaDepartment of Biology, University of Waterloo, Waterloo, ON N2L3G1, Canada.
Terence D CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
University of Waterloo · CAHarvard University · USBroad Institute · USMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The angiotensin-converting enzyme 2 (ACE2) protein is a key catalytic regulator of the renin-angiotensin system (RAS), involved in fluid homeostasis and blood pressure modulation. ACE2 also serves as a cell-surface receptor for some coronaviruses such as

Indexed as

Biological sciencesImmunologyMolecular biologyVirology

Identifiers

PMID35756893
PMCPMC9213013
OpenAlexW4282943453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.