Evidence map›Paper›PMID 35756883›Full record

ArticlePhysics and imaging in radiation oncology2022

Quantitative analysis of diffusion weighted imaging in rectal cancer during radiotherapy using a magnetic resonance imaging integrated linear accelerator.

Manasi Ingle, Matthew Blackledge, Ingrid White, Andreas Wetscherek, Susan Lalondrelle, Shaista Hafeez, Shreerang Bhide

Open access · goldAbstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. MR-linac: role of artificial intelligence and automation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  6. Article
  7. Article
  8. Results of radical treatment of locally advanced rectal cancer in geriatric and non-geriatric patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Manasi IngleThe Royal Marsden Hospital NHS Trust, 203 Fulham Road, London SW3 6JJ, UK.
Matthew BlackledgeThe Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.
Ingrid WhiteGuys and St Thomas NHS Trust, Great Maze Pond, London SE1 9RT, UK.
Andreas WetscherekThe Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.
Susan LalondrelleThe Royal Marsden Hospital NHS Trust, 203 Fulham Road, London SW3 6JJ, UK.
Shaista HafeezThe Royal Marsden Hospital NHS Trust, 203 Fulham Road, London SW3 6JJ, UK.
Shreerang BhideThe Royal Marsden Hospital NHS Trust, 203 Fulham Road, London SW3 6JJ, UK.
Institute of Cancer Research · GBRoyal Marsden Hospital · GBRoyal Marsden NHS Foundation Trust · GBGuy's and St Thomas' NHS Foundation Trust · GB

Funding

Cancer Research UK 28284Cancer Research UK 28724
6 · The paper itself

Abstract

Background and purpose: Magnetic resonance imaging integrated linear accelerator (MR-Linac) platforms enable acquisition of diffusion weighted imaging (DWI) during treatment providing potential information about treatment response. Obtaining DWI on these platforms is technically different from diagnostic magnetic resonance imaging (MRI) scanners. The aim of this project was to determine feasibility of obtaining DWI and calculating apparent diffusion coefficient (ADC) parameters longitudinally in rectal cancer patients on the MR-Linac. Materials and methods: Nine patients undergoing treatment on MR-Linac had DWI acquired using b-values 0, 30, 150, 500 s/mm Results: Seven out of nine patients were included in the analysis; all demonstrated downstaging at follow-up. A total of 63 out of 70 DWI were analysed (7 excluded due to poor image quality). An increasing trend of ADC median for GTV (1.15 × 10 Conclusions: DWI assessment in rectal cancer patients on MR-Linac is feasible. Initial results provide foundations for further studies to determine DWI use for treatment adaptation in rectal cancer.

Indexed as

Apparent diffusion coefficientDiffusion weighted imagingMRIMR-LinacRectal cancer

Identifiers

PMID35756883
PMCPMC9214864
OpenAlexW4281618808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.