ArticleACS central science2022
Instant Adhesion of Amyloid-like Nanofilms with Wet Surfaces.
Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.Nature communications · 2026Article
- Adhesion Mechanisms of Amyloid-Like Oligomer Monolayers Enabling Stable Surface Modification for Inert Polymers.JACS Au · 2026Article
- From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications.ACS applied materials & interfaces · 2025Review
- Fabrication of Free-Standing Gelatin Thin Films via the Gelation and Drying of Liquid Foam Films.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Living/controlled supramolecular protein polymerization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recent Advances in Amyloids Structural Studies and Thin Film Applications.Molecules (Basel, Switzerland) · 2025Review
- An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery.Science advances · 2025Article
- Construction of an HBPL antibacterial coating on a phase-transition lysozyme-modified titanium surface.Frontiers in oral health · 2025Article
- Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment.Theranostics · 2025Review
- Emerging novel hydrogels application in oral and gastrointestinal diseases: design wet adhesive strategy towards possible mechanisms.Science and technology of advanced materials · 2025Review
- Cyclosporine a in the treatment of dry eye disease: a narrative review.Frontiers in ophthalmology · 2025Review
- Functionalized Amyloid-Like Protein Nanofilm-Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer.Small science · 2024Article
- Non-fibril amyloid aggregation at the air/water interface: self-adaptive pathway resulting in a 2D Janus nanofilm.Chemical science · 2024Article
- A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation.Science advances · 2024Article
- Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation.Nature protocols · 2024Review
- Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease.Gels (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adhesion and modification of wet surfaces by an interfacial adlayer remain a key challenge in chemistry and materials science. Herein, we report a transparent and biocompatible amyloid-like nanofilm that breaks through the hydration layer of a wet surface and achieves strong adhesion with a hydrogel/tissue surface within 2 s. This process is facilitated by fast amyloid-like protein aggregation at the air/water interface and the resultant exposure of hydrophobic groups. The resultant protein nanofilm adhered to a hydrogel surface presents an adhesion strength that is 20 times higher than the maximum friction force between the upper eyelid and eyeball. In addition, the nanofilm exhibits controllable tunability to encapsulate and release functional molecules without significant activity loss. As a result, therapeutic contact lenses (CLs) could be fabricated by adhering the functionalized nanofilm (carrying drug) on the CL surface. These therapeutic CLs display excellent therapeutic efficacy, showing an increase in cyclosporin A (CsA) bioavailability of at least 82% when compared to the commercial pharmacologic treatment for dry eye syndrome. Thus, this work underlines the finding that the bioinspired amyloid-like aggregation of proteins at interfaces drives instant adhesion onto a wet surface, enabling the active loading and controllable release of functional building blocks.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.