ArticleSleep science (Sao Paulo, Brazil)
The effectiveness of caffeinated chewing gum in ameliorating cognitive functions affected by sleep deprivation.
Article in Sleep science (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The effects of mental fatigue and caffeine on basketball performance: insights from a crossover study.Journal of the International Society of Sports Nutrition · 2025Trial
- Are caffeine effects equivalent between different modes of administration: the acute effects of 3 mg.kgJournal of the International Society of Sports Nutrition · 2024Trial
- Novel Soft Dosage Forms for Paediatric Applications: Can We 3D-Print Them or Not?Gels (Basel, Switzerland) · 2025Review
- Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial.Frontiers in oral health · 2025Article
- Formulation Consideration of Medicated Chewing Gum: A Review.Recent advances in drug delivery and formulation · 2024Review
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This investigation aimed to compare caffeinated gums with two different dosages of caffeine (200mg vs. 300mg) by assessing their effectiveness on the improvement of cognitive functions among Iranian individuals voluntarily suffering from 30 hours of sleep deprivation. Material and Methods: Thirty-four healthy male volunteers with ages from 28 to 35 years old were randomly assigned to either 200 or 300mg caffeine intake. Each participant completed CANTAB subtests to assess their core cognitive functions including MOT, RTI, RVP, and SWM before and after sleep deprivation, as well as after being treated with caffeinated gum. Results: The 300mg caffeine intake group indicated higher levels of enhancement of core cognitive functions compared with those in the 200mg caffeine intake group. Conclusion: This study suggests that the dose of 300mg of caffeine could effectively enhance the cognitive functions of Iranian individuals suffering from sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.