Evidence map›Paper›PMID 35755857›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2022

Validation of a Simple, Rapid, and Cost-Effective Method for Acute Rejection Monitoring in Lung Transplant Recipients.

Monica Sorbini, Gabriele Togliatto, Fiorenza Mioli, Erika Simonato, Matteo Marro, Margherita Cappuccio, Francesca Arruga, Cristiana Caorsi, Morteza Mansouri, Paola Magistroni and 10 more

Open access · goldAbstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Exploring acute cellular rejection in lung transplantation: insights from donor-derived cell-free DNA analysis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
    Article
  3. Article
  4. Article
  5. Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Molecular monitoring of lung allograft health: is it ready for routine clinical use?European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  15. Article
  16. Article
  17. Relevant biomarkers of kidney allograft rejection.Journal of medicine and life · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Monica SorbiniDepartment of Medical Sciences, University of Turin, Turin, Italy.
Gabriele TogliattoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Fiorenza MioliDepartment of Medical Sciences, University of Turin, Turin, Italy.
Erika SimonatoCardiac Surgery Division, Surgical Sciences Department, Heart and Lung Transplant Center, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Matteo MarroCardiac Surgery Division, Surgical Sciences Department, Heart and Lung Transplant Center, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Margherita CappuccioDepartment of Medical Sciences, University of Turin, Turin, Italy.
Francesca ArrugaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Cristiana CaorsiImmunogenetics and Transplant Biology Service, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Morteza MansouriImmunogenetics and Transplant Biology Service, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Paola MagistroniImmunogenetics and Transplant Biology Service, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Alessandro GambellaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Luisa DelsedimePathology Unit, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Mauro Giulio PapottiPathology Unit, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Paolo SolidoroLung Transplantation and Advanced Airways Management, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Carlo AlberaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Massimo BoffiniCardiac Surgery Division, Surgical Sciences Department, Heart and Lung Transplant Center, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Mauro RinaldiCardiac Surgery Division, Surgical Sciences Department, Heart and Lung Transplant Center, Città Della Salute e Della Scienza University Hospital, Turin, Italy.
Antonio AmorosoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Tiziana VaisittiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Silvia DeaglioDepartment of Medical Sciences, University of Turin, Turin, Italy.
University of Turin · ITEuropean School of Oncology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in immunosuppression therapy, acute rejection remains the leading cause of graft dysfunction in lung transplant recipients. Donor-derived cell-free DNA is increasingly being considered as a valuable biomarker of acute rejection in several solid organ transplants. We present a technically improved molecular method based on digital PCR that targets the mismatch between the recipient and donor at the

Indexed as

Cell-Free Nucleic AcidsTransplant RecipientsCost-Benefit AnalysisGraft RejectionHumansLungTissue DonorsCell-Free Nucleic Acidsacute rejectionbiomarkercell free circulating DNAdroplet-digital PCRlung transplantation

Identifiers

PMID35755857
PMCPMC9221674
OpenAlexW4281776524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.