Evidence map›Paper›PMID 35755475›Full record

ArticleIJID regions2022

Risk-adjusted active tuberculosis case finding strategy in central Ethiopia.

Andre Fuchs, Tafese Beyene Tufa, Frieder Pfäfflin, Andreas Schönfeld, Tamara Nordmann, Fikru Melaku, Abebe Sorsa, Hans Martin Orth, Dieter Häussinger, Tom Luedde and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJID regions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Andre FuchsHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Tafese Beyene TufaHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Frieder PfäfflinDepartment for Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Andreas SchönfeldDepartment of Infectious Diseases, West German Centre of Infectious Diseases, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
Tamara NordmannDepartment of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fikru MelakuAdama Public Health Research and Referral Laboratory Center, Adama, Ethiopia.
Abebe SorsaCollege of Health Sciences, Arsi University, Asella, Ethiopia.
Hans Martin OrthHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Dieter HäussingerHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Tom LueddeHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Torsten FeldtHirsch Institute of Tropical Medicine, Asella, Ethiopia.
Düsseldorf University Hospital · DEAdama Science and Technology University · ETAsossa University · ETEssen University Hospital · DEHumboldt-Universität zu Berlin · DEUniversität Hamburg · DEUniversity Hospital Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The World Health Organization recommends active case finding for tuberculosis (TB). Our study evaluated the targeted screening of household contacts (HHCs) of patients with contagious pulmonary tuberculosis (PTB) in Central Ethiopia. Methods: The HHCs of patients with microbiologically confirmed PTB were screened for TB symptoms and risk factors for TB transmission. Symptomatic HHCs were subjected to secondary investigation. Antimicrobial resistance was investigated among study participants. Results: Overall, 112 index patients with TB were included, and 289 HHCs from 89 households were screened. Multidrug-resistant-TB was detected in 2.7% (n=3) of index patients. The routine public health system process did not identify any TB suspects among HHCs. In total, 23.9% (n=69) of HHCs reported ≥1 TB symptom and PTB was confirmed in 2.1% (n=6). Reporting >1 TB symptom (relative risk [RR] 29.4, 95% CI 3.5-245.5, Conclusion: The MDR-TB rate among our patients was higher than recently reported for Ethiopia. Enhanced contact tracing using a risk-adjusted approach seems feasible and increases the case detection rate among HHCs of confirmed TB cases.

Indexed as

AfricaContact tracingHousehold contactsHousehold membersTB

Identifiers

PMID35755475
PMCPMC9216629
OpenAlexW4220967638

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.